Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966265564> ?p ?o ?g. }
- W1966265564 endingPage "2362" @default.
- W1966265564 startingPage "2354" @default.
- W1966265564 abstract "Muscle contusions are the most common muscle injuries in sports medicine. Although these injuries are capable of healing, incomplete functional recovery often occurs.Suramin enhances muscle healing by both stimulating muscle regeneration and preventing fibrosis in contused skeletal muscle.Controlled laboratory study.In vitro: Myoblasts (C2C12 cells) and muscle-derived stem cells (MDSCs) were cultured with suramin, and the potential of suramin to induce their differentiation was evaluated. Furthermore, MDSCs were cocultured with suramin and myostatin (MSTN) to monitor the capability of suramin to neutralize the effect of MSTN. In vivo: Varying concentrations of suramin were injected in the tibialis anterior muscle of mice 2 weeks after muscle contusion injury. Muscle regeneration and scar tissue formation were evaluated by histologic analysis and functional recovery was measured by physiologic testingIn vitro: Suramin stimulated the differentiation of myoblasts and MDSCs in a dose-dependent manner. Moreover, suramin neutralized the inhibitory effect of MSTN on MDSC differentiation. In vivo: Suramin treatment significantly promoted muscle regeneration, decreased fibrosis formation, reduced myostatin expression in injured muscle, and increased muscle strength after contusion injury.Intramuscular injection of suramin after a contusion injury improved overall skeletal muscle healing. Suramin enhanced myoblast and MDSC differentiation and neutralized MSTN's negative effect on myogenic differentiation in vitro, which suggests a possible mechanism for the beneficial effects that this pharmacologic agent exhibits in vivo.These findings could contribute to the development of biological treatments to aid in muscle healing after experiencing a muscle injury." @default.
- W1966265564 created "2016-06-24" @default.
- W1966265564 creator A5011284255 @default.
- W1966265564 creator A5034485107 @default.
- W1966265564 creator A5042181613 @default.
- W1966265564 creator A5049355169 @default.
- W1966265564 creator A5049912939 @default.
- W1966265564 creator A5073927730 @default.
- W1966265564 creator A5074208816 @default.
- W1966265564 date "2008-08-25" @default.
- W1966265564 modified "2023-10-14" @default.
- W1966265564 title "Improved Muscle Healing after Contusion Injury by the Inhibitory Effect of Suramin on Myostatin, a Negative Regulator of Muscle Growth" @default.
- W1966265564 cites W1044931647 @default.
- W1966265564 cites W139077540 @default.
- W1966265564 cites W1441043383 @default.
- W1966265564 cites W1897782182 @default.
- W1966265564 cites W1904407182 @default.
- W1966265564 cites W1942760864 @default.
- W1966265564 cites W1968814074 @default.
- W1966265564 cites W1969239521 @default.
- W1966265564 cites W1969922068 @default.
- W1966265564 cites W1976978033 @default.
- W1966265564 cites W1986797003 @default.
- W1966265564 cites W1988668250 @default.
- W1966265564 cites W1992148727 @default.
- W1966265564 cites W1993945665 @default.
- W1966265564 cites W1997639385 @default.
- W1966265564 cites W2000207280 @default.
- W1966265564 cites W2007181417 @default.
- W1966265564 cites W2012745472 @default.
- W1966265564 cites W2012831661 @default.
- W1966265564 cites W2019828972 @default.
- W1966265564 cites W2021243618 @default.
- W1966265564 cites W2030115811 @default.
- W1966265564 cites W2031961257 @default.
- W1966265564 cites W2033331798 @default.
- W1966265564 cites W2041748795 @default.
- W1966265564 cites W2045954662 @default.
- W1966265564 cites W2050470509 @default.
- W1966265564 cites W2050511526 @default.
- W1966265564 cites W2051437976 @default.
- W1966265564 cites W2061827083 @default.
- W1966265564 cites W2062867597 @default.
- W1966265564 cites W2062964067 @default.
- W1966265564 cites W2071590971 @default.
- W1966265564 cites W2075225107 @default.
- W1966265564 cites W2079359838 @default.
- W1966265564 cites W2084565669 @default.
- W1966265564 cites W2087144973 @default.
- W1966265564 cites W2087924428 @default.
- W1966265564 cites W2094255224 @default.
- W1966265564 cites W2135722738 @default.
- W1966265564 cites W2137593257 @default.
- W1966265564 cites W2158354352 @default.
- W1966265564 cites W2316312280 @default.
- W1966265564 cites W2399937467 @default.
- W1966265564 cites W4238262373 @default.
- W1966265564 cites W4253731316 @default.
- W1966265564 cites W4381986023 @default.
- W1966265564 doi "https://doi.org/10.1177/0363546508322886" @default.
- W1966265564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18725651" @default.
- W1966265564 hasPublicationYear "2008" @default.
- W1966265564 type Work @default.
- W1966265564 sameAs 1966265564 @default.
- W1966265564 citedByCount "90" @default.
- W1966265564 countsByYear W19662655642012 @default.
- W1966265564 countsByYear W19662655642013 @default.
- W1966265564 countsByYear W19662655642014 @default.
- W1966265564 countsByYear W19662655642015 @default.
- W1966265564 countsByYear W19662655642016 @default.
- W1966265564 countsByYear W19662655642017 @default.
- W1966265564 countsByYear W19662655642018 @default.
- W1966265564 countsByYear W19662655642019 @default.
- W1966265564 countsByYear W19662655642020 @default.
- W1966265564 countsByYear W19662655642021 @default.
- W1966265564 countsByYear W19662655642022 @default.
- W1966265564 crossrefType "journal-article" @default.
- W1966265564 hasAuthorship W1966265564A5011284255 @default.
- W1966265564 hasAuthorship W1966265564A5034485107 @default.
- W1966265564 hasAuthorship W1966265564A5042181613 @default.
- W1966265564 hasAuthorship W1966265564A5049355169 @default.
- W1966265564 hasAuthorship W1966265564A5049912939 @default.
- W1966265564 hasAuthorship W1966265564A5073927730 @default.
- W1966265564 hasAuthorship W1966265564A5074208816 @default.
- W1966265564 hasConcept C126322002 @default.
- W1966265564 hasConcept C134018914 @default.
- W1966265564 hasConcept C150903083 @default.
- W1966265564 hasConcept C170493617 @default.
- W1966265564 hasConcept C171056886 @default.
- W1966265564 hasConcept C207001950 @default.
- W1966265564 hasConcept C207200792 @default.
- W1966265564 hasConcept C2776182878 @default.
- W1966265564 hasConcept C2777488582 @default.
- W1966265564 hasConcept C2779959927 @default.
- W1966265564 hasConcept C2780559512 @default.
- W1966265564 hasConcept C71924100 @default.
- W1966265564 hasConcept C86803240 @default.
- W1966265564 hasConcept C95444343 @default.