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- W1966265764 abstract "Concentrations of morphine, morphine-3-glucuronide (M3G) and morphine-6- glucuronide (M6G) were measured by h.p.l.c. in plasma and cerebrospinal fluid (CSF) samples from 16 patients with cancer receiving oral (controlled-release) morphine. There was a close correlation between plasma and CSF morphine concentrations (r = 0.94, P = 0.0001) and both correlated with drug dosage (r = 0.61, P = 0.013 and r = 0.74, P = 0.0001, respectively). M3G and M6G in plasma and CSF were correlated (r = 0.81 and r = 0.82, both P = 0.0001). No relationship was apparent between M plus M6G concentrations in the CSF and pain scores." @default.
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- W1966265764 date "1994-09-01" @default.
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- W1966265764 title "Morphine and morphine-glucuronide concentrations in plasma and CSF during long-term administration of oral morphine." @default.
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- W1966265764 doi "https://doi.org/10.1111/j.1365-2125.1994.tb04352.x" @default.
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