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- W1966269027 abstract "DRUG-ELUTING STENTS HAVE revolutionized the treatment of atherosclerotic coronary artery disease. The demonstration that both sirolimus-eluting and paclitaxel-eluting stents safely reduce clinical and angiographic restenosis compared with bare metal stents has resulted in an estimated 160 000 of these devices currently being implanted per month worldwide (unpublished data, Boston Scientific Corp, Natick, Mass), signifying drug-eluting stents as by far the most widely used permanent bioprosthesis. Enrollment in the pivotal randomized trials, however, was restricted to relatively simple stenoses (vessel diameter of 2.5-3.75 mm with lesion length 30 mm). More than 55% of lesions currently treated with these bioactive devices may fall outside this range. The efficacy of drugeluting stents has not been established for small vessels (in which the utility of For editorial comment see p 1268. Author Affiliations are listed at the end of this article. TAXUS V Principal Investigators and Institutions appear at the end of this article. Corresponding Author: Gregg W. Stone, MD, Columbia University Medical Center, Herbert Irving Pavilion, Fifth Floor, 161 Fort Washington Ave, New York, NY 10032 (gs2184@columbia.edu). Context Compared with bare metal stents, drug-eluting stents reduce restenosis in noncomplex lesions. The utility of drug-eluting stents has not been evaluated in more difficult stenoses." @default.
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- W1966269027 date "2005-12-01" @default.
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- W1966269027 title "Comparison of a Polymer-Based Paclitaxel-Eluting Stent With a Bare Metal Stent in Patients With Complex Coronary Artery Disease: A Randomized Controlled Trial" @default.
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