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• W1966271519 endingPage "458" @default.
• W1966271519 startingPage "447" @default.
• W1966271519 abstract "Shogaols, a series of major constituents in dried ginger with the most abundant being [6]-, [8]-, and [10]-shogaols, show much higher anticancer potencies than gingerols. Previously, we reported the mercapturic acid pathway as a major metabolic route for [6]-shogaol in mice. However, it is still unclear how the side chain length affects the metabolism of shogaols and how shogaols are metabolized in humans.We first investigate the metabolism of [10]-shogaol in mouse urine, and then investigate the biotransformation of shogaols in human urine. Our results show that eight major thiol-conjugated metabolites of [10]-shogaol were detected in mouse urine, while six major thiol-conjugated metabolites of [6]-shogaol, two thiol-conjugated metabolites of [8]-shogaol, and two thiol-conjugated metabolites of [10]-shogaol were detected in urine collected from human after drinking ginger tea, using LC/ESI-MS/MS. Our results clearly indicate the mercapturic acid pathway is a major metabolic route for [10]-shogaol in mice and for shogaols in human. Furthermore, we also investigated the regulation of glutathione (GSH) by [6]-shogaol in human colon cancer cells HCT-116. Our results show [6]-shogaol, after initially depleting glutathione levels, can subsequently restore and increase GSH levels over time.Shogaols are metabolized extensively in mouse and human to form thiol-conjugated metabolites and GSH might play an important role in the cancer-preventive activity of ginger." @default.
• W1966271519 created "2016-06-24" @default.
• W1966271519 creator A5002532343 @default.
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• W1966271519 date "2013-01-16" @default.
• W1966271519 modified "2023-10-12" @default.
• W1966271519 title "Characterization of thiol‐conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]‐shogaol" @default.
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• W1966271519 doi "https://doi.org/10.1002/mnfr.201200679" @default.
• W1966271519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3817846" @default.
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