FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966276708> ?p ?o ?g. }

• W1966276708 endingPage "10" @default.
• W1966276708 startingPage "1" @default.
• W1966276708 abstract "The PISCF-allatostatins (Manduca sexta- or C-type allatostatins) are a family of pentadecapeptides characterized by a pyroglutamine blocked N-terminus, an unamidated-PISCF C-terminus, and a disulfide bridge between two internal Cys residues. Several isoforms of PISCF-AST are known, all from holometabolous insects. Using a combination of transcriptomics and mass spectrometry, we have identified the first PISCF-type peptides from a non-insect species. In silico analysis of crustacean ESTs identified several Litopenaeus vannamei (infraorder Penaeidea) transcripts encoding putative PISCF-AST precursors. Translation of these ESTs, with subsequent prediction of their putative post-translational processing, revealed the existence of as many as three PISCF-type peptides, including pQIRYHQCYFNPISCF (disulfide bridging between Cys(7) and Cys(14)). Although none of the predicted isoforms was detected by mass spectrometry in L. vannamei, MALDI-FTMS mass profiling identified an m/z signal corresponding to pQIRYHQCYFNPISCF (disulfide bridge present) in neural tissue from 28 other decapods, which included members of six infraorders (Stenopodidea, Astacidea, Thalassinidea, Achelata, Anomura and Brachyura). Further characterization of the peptide using SORI-CID and chemical derivatization/enzymatic digestion supported the theorized structure. In both the crab Cancer borealis and the lobster Homarus americanus, MALDI-based tissue surveys suggest that pQIRYHQCYFNPISCF is broadly distributed in the nervous system; it was also detected in the posterior midgut caecum. Collectively, our data show that members of the PISCF-AST family are not restricted to the holometabolous insects, but instead may be broadly conserved within the Pancrustacea. Moreover, our data suggest that one highly conserved PISCF-type peptide, pQIRYHQCYFN-PISCF, is present in decapod crustaceans, functioning as a brain-gut paracrine/hormone." @default.
• W1966276708 created "2016-06-24" @default.
• W1966276708 creator A5000651693 @default.
• W1966276708 creator A5033244653 @default.
• W1966276708 creator A5038815110 @default.
• W1966276708 creator A5057881385 @default.
• W1966276708 creator A5068678816 @default.
• W1966276708 date "2010-01-01" @default.
• W1966276708 modified "2023-09-25" @default.
• W1966276708 title "Molecular and mass spectral identification of the broadly conserved decapod crustacean neuropeptide pQIRYHQCYFNPISCF: The first PISCF-allatostatin (Manduca sexta- or C-type allatostatin) from a non-insect" @default.
• W1966276708 cites W1495926848 @default.
• W1966276708 cites W1965283959 @default.
• W1966276708 cites W1969960855 @default.
• W1966276708 cites W1974688045 @default.
• W1966276708 cites W1979071260 @default.
• W1966276708 cites W1986220579 @default.
• W1966276708 cites W1987996415 @default.
• W1966276708 cites W1988331575 @default.
• W1966276708 cites W1994829369 @default.
• W1966276708 cites W2002773067 @default.
• W1966276708 cites W2010065384 @default.
• W1966276708 cites W2011533351 @default.
• W1966276708 cites W2012314006 @default.
• W1966276708 cites W2014715854 @default.
• W1966276708 cites W2017989795 @default.
• W1966276708 cites W2026984410 @default.
• W1966276708 cites W2028438413 @default.
• W1966276708 cites W2032325801 @default.
• W1966276708 cites W2036962167 @default.
• W1966276708 cites W2043447223 @default.
• W1966276708 cites W2044416680 @default.
• W1966276708 cites W2050123774 @default.
• W1966276708 cites W2052363451 @default.
• W1966276708 cites W2054279259 @default.
• W1966276708 cites W2056877196 @default.
• W1966276708 cites W2059306536 @default.
• W1966276708 cites W2082380119 @default.
• W1966276708 cites W2083290871 @default.
• W1966276708 cites W2090970892 @default.
• W1966276708 cites W2099383076 @default.
• W1966276708 cites W2106452753 @default.
• W1966276708 cites W2108885746 @default.
• W1966276708 cites W2126541983 @default.
• W1966276708 cites W2126972092 @default.
• W1966276708 cites W2134346308 @default.
• W1966276708 cites W2138089548 @default.
• W1966276708 cites W2142444973 @default.
• W1966276708 cites W2157666894 @default.
• W1966276708 cites W2161746138 @default.
• W1966276708 cites W2168964292 @default.
• W1966276708 cites W2225167171 @default.
• W1966276708 doi "https://doi.org/10.1016/j.ygcen.2009.05.010" @default.
• W1966276708 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3538855" @default.
• W1966276708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19467234" @default.
• W1966276708 hasPublicationYear "2010" @default.
• W1966276708 type Work @default.
• W1966276708 sameAs 1966276708 @default.
• W1966276708 citedByCount "49" @default.
• W1966276708 countsByYear W19662767082012 @default.
• W1966276708 countsByYear W19662767082013 @default.
• W1966276708 countsByYear W19662767082014 @default.
• W1966276708 countsByYear W19662767082015 @default.
• W1966276708 countsByYear W19662767082016 @default.
• W1966276708 countsByYear W19662767082017 @default.
• W1966276708 countsByYear W19662767082018 @default.
• W1966276708 countsByYear W19662767082019 @default.
• W1966276708 countsByYear W19662767082020 @default.
• W1966276708 countsByYear W19662767082021 @default.
• W1966276708 countsByYear W19662767082022 @default.
• W1966276708 countsByYear W19662767082023 @default.
• W1966276708 crossrefType "journal-article" @default.
• W1966276708 hasAuthorship W1966276708A5000651693 @default.
• W1966276708 hasAuthorship W1966276708A5033244653 @default.
• W1966276708 hasAuthorship W1966276708A5038815110 @default.
• W1966276708 hasAuthorship W1966276708A5057881385 @default.
• W1966276708 hasAuthorship W1966276708A5068678816 @default.
• W1966276708 hasBestOaLocation W19662767082 @default.
• W1966276708 hasConcept C118303440 @default.
• W1966276708 hasConcept C170493617 @default.
• W1966276708 hasConcept C2777612826 @default.
• W1966276708 hasConcept C2779252662 @default.
• W1966276708 hasConcept C2780118809 @default.
• W1966276708 hasConcept C2780312687 @default.
• W1966276708 hasConcept C55493867 @default.
• W1966276708 hasConcept C59822182 @default.
• W1966276708 hasConcept C84766238 @default.
• W1966276708 hasConcept C86803240 @default.
• W1966276708 hasConcept C90856448 @default.
• W1966276708 hasConceptScore W1966276708C118303440 @default.
• W1966276708 hasConceptScore W1966276708C170493617 @default.
• W1966276708 hasConceptScore W1966276708C2777612826 @default.
• W1966276708 hasConceptScore W1966276708C2779252662 @default.
• W1966276708 hasConceptScore W1966276708C2780118809 @default.
• W1966276708 hasConceptScore W1966276708C2780312687 @default.
• W1966276708 hasConceptScore W1966276708C55493867 @default.
• W1966276708 hasConceptScore W1966276708C59822182 @default.
• W1966276708 hasConceptScore W1966276708C84766238 @default.
• W1966276708 hasConceptScore W1966276708C86803240 @default.

• next