FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966280283> ?p ?o ?g. }

• W1966280283 endingPage "988" @default.
• W1966280283 startingPage "983" @default.
• W1966280283 abstract "Monocytes are central to the initiation of the inflammatory response in sepsis, with caspase-1 activation playing a key role. Monocyte deactivation during sepsis has been linked to poor outcomes.Given the importance of caspase-1 in the immune response, we investigated whether monocytes from patients early in septic shock demonstrate alterations in mRNAs for caspase-1-related molecules.Patients with septic shock (n = 26; age >18 years), critically ill intensive care unit patients (n = 20), and healthy volunteers (n = 22) were enrolled in a prospective cohort study in a university intensive care unit. Demographic, biological, physiologic, and plasma cytokine measurements were obtained. Monocytes were assayed for ex vivo tumor necrosis factor-alpha production, and fresh monocyte mRNA was analyzed by quantitative reverse-transcription polymerase chain reaction for Toll-like receptors, NOD-LRR proteins, cytokines, and nuclear factor-kappaB-related genes.Relative copy numbers for the inflammasome mRNAs for ASC, caspase-1, NALP1, and Pypaf-7 were significantly lower in patients with septic shock compared with critically ill control subjects. NALP1 mRNA levels were linked to survival in patients with sepsis (P = 0.0068) and correlated with SAPS II scores (r = -0.63).These data suggest that monocyte deactivation occurs during the earliest stages of the systemic inflammatory response and that changes in inflammasome mRNA expression are part of this process." @default.
• W1966280283 created "2016-06-24" @default.
• W1966280283 creator A5000563627 @default.
• W1966280283 creator A5006086483 @default.
• W1966280283 creator A5006499471 @default.
• W1966280283 creator A5007779144 @default.
• W1966280283 creator A5019249857 @default.
• W1966280283 creator A5019357352 @default.
• W1966280283 creator A5021114281 @default.
• W1966280283 creator A5024840875 @default.
• W1966280283 creator A5026014458 @default.
• W1966280283 creator A5061477685 @default.
• W1966280283 creator A5087672793 @default.
• W1966280283 creator A5091688364 @default.
• W1966280283 date "2008-05-01" @default.
• W1966280283 modified "2023-10-18" @default.
• W1966280283 title "Inflammasome mRNA Expression in Human Monocytes during Early Septic Shock" @default.
• W1966280283 cites W1489842152 @default.
• W1966280283 cites W1529674879 @default.
• W1966280283 cites W1559077578 @default.
• W1966280283 cites W1571910978 @default.
• W1966280283 cites W1921587687 @default.
• W1966280283 cites W1940869776 @default.
• W1966280283 cites W1972757665 @default.
• W1966280283 cites W1973329998 @default.
• W1966280283 cites W1977728930 @default.
• W1966280283 cites W1995744610 @default.
• W1966280283 cites W2003362321 @default.
• W1966280283 cites W2005111715 @default.
• W1966280283 cites W2008261126 @default.
• W1966280283 cites W2020908160 @default.
• W1966280283 cites W2026053343 @default.
• W1966280283 cites W2030023942 @default.
• W1966280283 cites W2039820190 @default.
• W1966280283 cites W2040068581 @default.
• W1966280283 cites W2052798287 @default.
• W1966280283 cites W2056589112 @default.
• W1966280283 cites W2058852263 @default.
• W1966280283 cites W2066904343 @default.
• W1966280283 cites W2077308121 @default.
• W1966280283 cites W2080354420 @default.
• W1966280283 cites W2085911628 @default.
• W1966280283 cites W2087203965 @default.
• W1966280283 cites W2088220499 @default.
• W1966280283 cites W2101191856 @default.
• W1966280283 cites W2120095910 @default.
• W1966280283 cites W2125062833 @default.
• W1966280283 cites W2157985992 @default.
• W1966280283 cites W2163657805 @default.
• W1966280283 cites W5242891 @default.
• W1966280283 doi "https://doi.org/10.1164/rccm.200703-418oc" @default.
• W1966280283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2361424" @default.
• W1966280283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18263805" @default.
• W1966280283 hasPublicationYear "2008" @default.
• W1966280283 type Work @default.
• W1966280283 sameAs 1966280283 @default.
• W1966280283 citedByCount "77" @default.
• W1966280283 countsByYear W19662802832012 @default.
• W1966280283 countsByYear W19662802832013 @default.
• W1966280283 countsByYear W19662802832014 @default.
• W1966280283 countsByYear W19662802832015 @default.
• W1966280283 countsByYear W19662802832016 @default.
• W1966280283 countsByYear W19662802832017 @default.
• W1966280283 countsByYear W19662802832018 @default.
• W1966280283 countsByYear W19662802832019 @default.
• W1966280283 countsByYear W19662802832020 @default.
• W1966280283 countsByYear W19662802832021 @default.
• W1966280283 countsByYear W19662802832022 @default.
• W1966280283 countsByYear W19662802832023 @default.
• W1966280283 crossrefType "journal-article" @default.
• W1966280283 hasAuthorship W1966280283A5000563627 @default.
• W1966280283 hasAuthorship W1966280283A5006086483 @default.
• W1966280283 hasAuthorship W1966280283A5006499471 @default.
• W1966280283 hasAuthorship W1966280283A5007779144 @default.
• W1966280283 hasAuthorship W1966280283A5019249857 @default.
• W1966280283 hasAuthorship W1966280283A5019357352 @default.
• W1966280283 hasAuthorship W1966280283A5021114281 @default.
• W1966280283 hasAuthorship W1966280283A5024840875 @default.
• W1966280283 hasAuthorship W1966280283A5026014458 @default.
• W1966280283 hasAuthorship W1966280283A5061477685 @default.
• W1966280283 hasAuthorship W1966280283A5087672793 @default.
• W1966280283 hasAuthorship W1966280283A5091688364 @default.
• W1966280283 hasBestOaLocation W19662802832 @default.
• W1966280283 hasConcept C126322002 @default.
• W1966280283 hasConcept C139964883 @default.
• W1966280283 hasConcept C141071460 @default.
• W1966280283 hasConcept C177713679 @default.
• W1966280283 hasConcept C17991360 @default.
• W1966280283 hasConcept C203014093 @default.
• W1966280283 hasConcept C2776376669 @default.
• W1966280283 hasConcept C2776914184 @default.
• W1966280283 hasConcept C2777209026 @default.
• W1966280283 hasConcept C2777628635 @default.
• W1966280283 hasConcept C2778165595 @default.
• W1966280283 hasConcept C2778384902 @default.
• W1966280283 hasConcept C2778690821 @default.
• W1966280283 hasConcept C2781184567 @default.
• W1966280283 hasConcept C2987404301 @default.

• next