Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966280980> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1966280980 endingPage "490" @default.
- W1966280980 startingPage "487" @default.
- W1966280980 abstract "The present study investigated proliferation of MKN28 and MKN45 human gastric cancer cells regulated by the N-methyl-d-aspartate (NMDA) receptor subunit. The NMDA receptor antagonist dl-2-amino-5-phosphonovaleric acid (AP5) inhibited proliferation of MKN45 cells, but not MKN28 cells. Of the NMDA subunits such as NR1, NR2 (2A, 2B, 2C, and 2D), and NR3 (3A and 3B), all the NMDA subunit mRNAs except for the NR2B subunit mRNA were expressed in both MKN28 and MKN45 cells. MKN45 cells were characterized by higher expression of the NR2A subunit mRNA and lower expression of the NR1 subunit mRNA, but MKN28 otherwise by higher expression of the NR1 subunit mRNA and lower expression of the NR2A subunit mRNA. MKN45 cell proliferation was also inhibited by silencing the NR2A subunit-targeted gene. For MKN45 cells, AP5 or knocking-down the NR2A subunit increased the proportion of cells in the G1 phase of cell cycling and decreased the proportion in the S/G2 phase. The results of the present study, thus, suggest that blockage of NMDA receptors including the NR2A subunit suppresses MKN45 cell proliferation due to cell cycle arrest at the G1 phase; in other words, the NR2A subunit promotes MKN45 cell proliferation by accelerating cell cycling." @default.
- W1966280980 created "2016-06-24" @default.
- W1966280980 creator A5020351940 @default.
- W1966280980 creator A5022159060 @default.
- W1966280980 creator A5037638547 @default.
- W1966280980 creator A5047240671 @default.
- W1966280980 creator A5061981088 @default.
- W1966280980 creator A5064520097 @default.
- W1966280980 date "2008-03-01" @default.
- W1966280980 modified "2023-09-30" @default.
- W1966280980 title "The NMDA receptor NR2A subunit regulates proliferation of MKN45 human gastric cancer cells" @default.
- W1966280980 cites W1559213768 @default.
- W1966280980 cites W1791741410 @default.
- W1966280980 cites W1965044975 @default.
- W1966280980 cites W1991494214 @default.
- W1966280980 cites W2025160847 @default.
- W1966280980 cites W2034862605 @default.
- W1966280980 cites W2036039158 @default.
- W1966280980 cites W2037678183 @default.
- W1966280980 cites W2088365972 @default.
- W1966280980 cites W2094476147 @default.
- W1966280980 cites W2095916340 @default.
- W1966280980 cites W2129761500 @default.
- W1966280980 cites W2158685104 @default.
- W1966280980 doi "https://doi.org/10.1016/j.bbrc.2007.12.167" @default.
- W1966280980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18178157" @default.
- W1966280980 hasPublicationYear "2008" @default.
- W1966280980 type Work @default.
- W1966280980 sameAs 1966280980 @default.
- W1966280980 citedByCount "51" @default.
- W1966280980 countsByYear W19662809802012 @default.
- W1966280980 countsByYear W19662809802013 @default.
- W1966280980 countsByYear W19662809802014 @default.
- W1966280980 countsByYear W19662809802015 @default.
- W1966280980 countsByYear W19662809802016 @default.
- W1966280980 countsByYear W19662809802017 @default.
- W1966280980 countsByYear W19662809802018 @default.
- W1966280980 countsByYear W19662809802019 @default.
- W1966280980 countsByYear W19662809802020 @default.
- W1966280980 countsByYear W19662809802021 @default.
- W1966280980 countsByYear W19662809802022 @default.
- W1966280980 countsByYear W19662809802023 @default.
- W1966280980 crossrefType "journal-article" @default.
- W1966280980 hasAuthorship W1966280980A5020351940 @default.
- W1966280980 hasAuthorship W1966280980A5022159060 @default.
- W1966280980 hasAuthorship W1966280980A5037638547 @default.
- W1966280980 hasAuthorship W1966280980A5047240671 @default.
- W1966280980 hasAuthorship W1966280980A5061981088 @default.
- W1966280980 hasAuthorship W1966280980A5064520097 @default.
- W1966280980 hasConcept C104292427 @default.
- W1966280980 hasConcept C104317684 @default.
- W1966280980 hasConcept C105580179 @default.
- W1966280980 hasConcept C153911025 @default.
- W1966280980 hasConcept C164083038 @default.
- W1966280980 hasConcept C170493617 @default.
- W1966280980 hasConcept C185592680 @default.
- W1966280980 hasConcept C55493867 @default.
- W1966280980 hasConcept C62112901 @default.
- W1966280980 hasConcept C67018056 @default.
- W1966280980 hasConcept C83730767 @default.
- W1966280980 hasConcept C86803240 @default.
- W1966280980 hasConcept C95444343 @default.
- W1966280980 hasConceptScore W1966280980C104292427 @default.
- W1966280980 hasConceptScore W1966280980C104317684 @default.
- W1966280980 hasConceptScore W1966280980C105580179 @default.
- W1966280980 hasConceptScore W1966280980C153911025 @default.
- W1966280980 hasConceptScore W1966280980C164083038 @default.
- W1966280980 hasConceptScore W1966280980C170493617 @default.
- W1966280980 hasConceptScore W1966280980C185592680 @default.
- W1966280980 hasConceptScore W1966280980C55493867 @default.
- W1966280980 hasConceptScore W1966280980C62112901 @default.
- W1966280980 hasConceptScore W1966280980C67018056 @default.
- W1966280980 hasConceptScore W1966280980C83730767 @default.
- W1966280980 hasConceptScore W1966280980C86803240 @default.
- W1966280980 hasConceptScore W1966280980C95444343 @default.
- W1966280980 hasIssue "2" @default.
- W1966280980 hasLocation W19662809801 @default.
- W1966280980 hasLocation W19662809802 @default.
- W1966280980 hasOpenAccess W1966280980 @default.
- W1966280980 hasPrimaryLocation W19662809801 @default.
- W1966280980 hasRelatedWork W2000529107 @default.
- W1966280980 hasRelatedWork W2001575559 @default.
- W1966280980 hasRelatedWork W2019883796 @default.
- W1966280980 hasRelatedWork W2028178374 @default.
- W1966280980 hasRelatedWork W2037141564 @default.
- W1966280980 hasRelatedWork W2086487208 @default.
- W1966280980 hasRelatedWork W2094869608 @default.
- W1966280980 hasRelatedWork W2119131843 @default.
- W1966280980 hasRelatedWork W2355509834 @default.
- W1966280980 hasRelatedWork W2367592316 @default.
- W1966280980 hasVolume "367" @default.
- W1966280980 isParatext "false" @default.
- W1966280980 isRetracted "false" @default.
- W1966280980 magId "1966280980" @default.
- W1966280980 workType "article" @default.