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- W1966281881 abstract "The bacterial outer membrane protein OmpX from Escherichia coli has been investigated by molecular dynamics simulations when embedded in a phospholipid bilayer and as a protein-micelle aggregate. The resulting simulation trajectories were analysed in terms of structural and dynamic properties of the membrane protein. In agreement with experimental observations, highest relative stability was found for the β-barrel region that is embedded in the lipophilic phase, whereas an extracellular protruding β-sheet, which is a unique structural feature of OmpX that supposedly plays an important role in cell adhesion and invasion, shows larger structure fluctuations. Additionally, we investigated water permeation into the core of the β-barrel protein, which contains a tight salt-bridge and hydrogen-bond network, so that extensive water flux is unlikely. Differences between the bilayer and the micellar system were observed in the length of the barrel and its position inside the lipid environment, and in the protein interactions with the hydrophilic part of the lipids near the lipid/water interface. Those variations suggest that micelles and other detergent environments might not offer a wholly membrane-like milieu to promote adoption of the physiological conformational state by OmpX." @default.
- W1966281881 created "2016-06-24" @default.
- W1966281881 creator A5000254356 @default.
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- W1966281881 date "2010-10-05" @default.
- W1966281881 modified "2023-09-26" @default.
- W1966281881 title "Membrane protein dynamics in different environments: simulation study of the outer membrane protein X in a lipid bilayer and in a micelle" @default.
- W1966281881 cites W1241092038 @default.
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- W1966281881 cites W1607188212 @default.
- W1966281881 cites W1607501108 @default.
- W1966281881 cites W1964279507 @default.
- W1966281881 cites W1964659291 @default.
- W1966281881 cites W1966858765 @default.
- W1966281881 cites W1968426540 @default.
- W1966281881 cites W1969129798 @default.
- W1966281881 cites W1969879204 @default.
- W1966281881 cites W1970351230 @default.
- W1966281881 cites W1979166300 @default.
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- W1966281881 cites W1995291690 @default.
- W1966281881 cites W2001708863 @default.
- W1966281881 cites W2001808731 @default.
- W1966281881 cites W2003468829 @default.
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- W1966281881 cites W2017304967 @default.
- W1966281881 cites W2022502227 @default.
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- W1966281881 doi "https://doi.org/10.1007/s00249-010-0626-7" @default.
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