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- W1966282014 abstract "A series of N-(3-(substituted-alkyl- or halophenyl)-4-methylthiazol-2(3H)-ylidene)-substituted alkyl- or halo-benzamides 21 - 40 were prepared by base-catalyzed cyclization of the corresponding 1-(substituted-alkyl- or halo-benzoyl)-3-(substituted-halophenyl)thioureas 1 - 20. Substituted pyrazolo[ 4,3-d]thiazol-5(6aH)-ylidene)benzamides 45a - d were synthesized by cycloaddition of compound 45 with the reactive cumulene intermediates 42a - d. All compounds were evaluated for their antiviral activity against the replication of HIV -1 and HIV-2 in MT-4. Compounds 35 and 39 showed an IC 50 of 2.02 μgmL −1 and 0.40 μgmL −1 against the HIV-2 strain ROD with CC 50 of ≥ 104.00 μgmL −1 and > 125.00 μgmL −1 , respectively, resulting in a selectivity index of ≥ 52 and > 313. Based on the chemical structure of compounds 35 and 39, these molecules can be proposed to act as NNRTIs. However, it is exceptional to observe an antiretroviral activity that is limited to HIV-2" @default.
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- W1966282014 date "2011-05-01" @default.
- W1966282014 modified "2023-09-26" @default.
- W1966282014 title "New Substituted Thiazol-2-ylidene-benzamides and Their Reaction with 1-Aza-2-azoniaallene Salts. Synthesis and anti-HIV Activity" @default.
- W1966282014 cites W2102094371 @default.
- W1966282014 doi "https://doi.org/10.1515/znb-2011-0512" @default.
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