Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966286998> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1966286998 endingPage "215" @default.
- W1966286998 startingPage "211" @default.
- W1966286998 abstract "<i>Background:</i> The enamel layerof kallikrein 4 (Klk4)-null mice has a normal thickness and a decussating pattern of enamel rods, but it contains residual enamel proteins, is less highly mineralized, and fractures in its deepest part just above the dentino-enamel junction (DEJ). The plane of fracture is puzzling because the deepest enamel is deposited earliest and, through the action of the secretory stage enamel protease (Mmp20), is the most mature part of the enamel layer at the time of the onset of <i>Klk4</i> expression. <i>Objectives:</i> To characterize the planes of fracture in <i>Mmp20-</i> and <i>Klk4</i>-null mice and to localize <i>Klk4</i> expression in developing teeth. <i>Methods:</i><i>Klk4</i>- and <i>Mmp20</i>-null mice were sacrificed at 7 weeks and their mandibular incisors were characterized by scanning electron microscopy. <i>Klk4</i><sup>+/</sup><sup>lac</sup><sup>Z</sup> mice were mated with <i>Klk4</i><sup>+/</sup><sup>lac</sup><sup>Z</sup> mice. Offspring were genotyped by polymerase chain reaction. <i>Klk4</i><sup>+/</sup><sup>+</sup>, <i>Klk4</i><sup>+/</sup><sup>lac</sup><sup>Z</sup>, and <i>Klk4</i><sup>lac</sup><sup>Z/</sup><sup>lac</sup><sup>Z</sup> (null) littermates on postnatal days 5, 8, 11, and 14 were processed for β-galactosidase histochemistry. <i>Results:</i> The enamel layer fractures at the DEJ in <i>Mmp20</i>-null mice, and fractures occur in enamel above the DEJ in <i>Klk4</i>-null mice. Klk4 is not expressed by secretory-stage ameloblasts, murine odontoblasts beneath the secretory stage, or maturation-stage ameloblasts. Klk4 is specifically expressed by transition and maturation-stage ameloblasts. <i>Conclusions:</i> The breakage of enamel near the DEJ in <i>Klk4</i>-null mice is not due to a failure of odontoblasts to express Klk4, but it relates to a progressive hypomineralization of enamel with depth." @default.
- W1966286998 created "2016-06-24" @default.
- W1966286998 creator A5006600622 @default.
- W1966286998 creator A5031564575 @default.
- W1966286998 creator A5041839098 @default.
- W1966286998 creator A5056462829 @default.
- W1966286998 creator A5061357064 @default.
- W1966286998 date "2011-01-01" @default.
- W1966286998 modified "2023-09-27" @default.
- W1966286998 title "Why Does Enamel in <i>Klk4</i>-Null Mice Break above the Dentino-Enamel Junction?" @default.
- W1966286998 cites W1976727209 @default.
- W1966286998 cites W2010795325 @default.
- W1966286998 cites W2023864912 @default.
- W1966286998 cites W2052457833 @default.
- W1966286998 cites W2060903489 @default.
- W1966286998 cites W2063734640 @default.
- W1966286998 cites W2071842869 @default.
- W1966286998 cites W2076815127 @default.
- W1966286998 cites W2082543973 @default.
- W1966286998 cites W2083754344 @default.
- W1966286998 cites W2085253491 @default.
- W1966286998 cites W2098184301 @default.
- W1966286998 cites W2102487925 @default.
- W1966286998 cites W2104084780 @default.
- W1966286998 cites W2104927261 @default.
- W1966286998 cites W2120230031 @default.
- W1966286998 cites W2124481587 @default.
- W1966286998 cites W2125237611 @default.
- W1966286998 cites W2130197365 @default.
- W1966286998 cites W2163540881 @default.
- W1966286998 cites W2168530048 @default.
- W1966286998 doi "https://doi.org/10.1159/000324260" @default.
- W1966286998 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3178080" @default.
- W1966286998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21546759" @default.
- W1966286998 hasPublicationYear "2011" @default.
- W1966286998 type Work @default.
- W1966286998 sameAs 1966286998 @default.
- W1966286998 citedByCount "25" @default.
- W1966286998 countsByYear W19662869982012 @default.
- W1966286998 countsByYear W19662869982013 @default.
- W1966286998 countsByYear W19662869982014 @default.
- W1966286998 countsByYear W19662869982015 @default.
- W1966286998 countsByYear W19662869982016 @default.
- W1966286998 countsByYear W19662869982017 @default.
- W1966286998 countsByYear W19662869982018 @default.
- W1966286998 countsByYear W19662869982019 @default.
- W1966286998 countsByYear W19662869982021 @default.
- W1966286998 countsByYear W19662869982023 @default.
- W1966286998 crossrefType "journal-article" @default.
- W1966286998 hasAuthorship W1966286998A5006600622 @default.
- W1966286998 hasAuthorship W1966286998A5031564575 @default.
- W1966286998 hasAuthorship W1966286998A5041839098 @default.
- W1966286998 hasAuthorship W1966286998A5056462829 @default.
- W1966286998 hasAuthorship W1966286998A5061357064 @default.
- W1966286998 hasBestOaLocation W19662869981 @default.
- W1966286998 hasConcept C106434640 @default.
- W1966286998 hasConcept C126322002 @default.
- W1966286998 hasConcept C134018914 @default.
- W1966286998 hasConcept C153911025 @default.
- W1966286998 hasConcept C156887251 @default.
- W1966286998 hasConcept C185592680 @default.
- W1966286998 hasConcept C199343813 @default.
- W1966286998 hasConcept C71924100 @default.
- W1966286998 hasConcept C86803240 @default.
- W1966286998 hasConceptScore W1966286998C106434640 @default.
- W1966286998 hasConceptScore W1966286998C126322002 @default.
- W1966286998 hasConceptScore W1966286998C134018914 @default.
- W1966286998 hasConceptScore W1966286998C153911025 @default.
- W1966286998 hasConceptScore W1966286998C156887251 @default.
- W1966286998 hasConceptScore W1966286998C185592680 @default.
- W1966286998 hasConceptScore W1966286998C199343813 @default.
- W1966286998 hasConceptScore W1966286998C71924100 @default.
- W1966286998 hasConceptScore W1966286998C86803240 @default.
- W1966286998 hasIssue "2-4" @default.
- W1966286998 hasLocation W19662869981 @default.
- W1966286998 hasLocation W19662869982 @default.
- W1966286998 hasLocation W19662869983 @default.
- W1966286998 hasLocation W19662869984 @default.
- W1966286998 hasOpenAccess W1966286998 @default.
- W1966286998 hasPrimaryLocation W19662869981 @default.
- W1966286998 hasRelatedWork W1016136338 @default.
- W1966286998 hasRelatedWork W1965799294 @default.
- W1966286998 hasRelatedWork W2017071525 @default.
- W1966286998 hasRelatedWork W2098184301 @default.
- W1966286998 hasRelatedWork W2103628652 @default.
- W1966286998 hasRelatedWork W2156988415 @default.
- W1966286998 hasRelatedWork W2329314857 @default.
- W1966286998 hasRelatedWork W2366370109 @default.
- W1966286998 hasRelatedWork W2748952813 @default.
- W1966286998 hasRelatedWork W4214695268 @default.
- W1966286998 hasVolume "194" @default.
- W1966286998 isParatext "false" @default.
- W1966286998 isRetracted "false" @default.
- W1966286998 magId "1966286998" @default.
- W1966286998 workType "article" @default.