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• W1966292270 abstract "Bursting activities were investigated under conditions of reduced outward K+ currents in neocortical slices obtained from rats presenting the gamma-aminobutyric acid (GABA)-withdrawal syndrome (GWS), a focal epilepsy consecutive to the interruption of a chronic intracortical GABA infusion into the somatomotor cortex. These bursts were induced by intracellular depolarizing current injection and/or by white matter stimulation. Tetraethylammonium (TEA) at doses which did not change input resistance, spike duration or first interspike time interval abolished the burst terminating process and induced plateau-like potentials (up to 500 ms) which were tetrodotoxin-resistant and blocked by Ca2+ antagonists Cd2+ and Co2+. Therefore, it appears that bursts during GWS are generated by Ca(2+)-dependent plateau potentials which are terminated by a K+ current highly sensitive to TEA." @default.
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• W1966292270 date "1995-04-01" @default.
• W1966292270 modified "2023-10-18" @default.
• W1966292270 title "A potassium current controls burst termination in rat neocortical neurons after GABA withdrawal" @default.
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• W1966292270 doi "https://doi.org/10.1016/0304-3940(95)11464-8" @default.
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