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- W1966295909 abstract "Objective To assess the effects of the angiotensin-converting enzyme inhibitor enalaprilat on endothelial cells in septic patients. Design Prospective, randomized, placebo-controlled, blinded study. Setting Clinical investigation on a surgical intensive care unit of a university hospital. Patients Forty surgical septic patients (noncardiac/nonneurosurgical patients). Interventions After inclusion in the study and after baseline data were obtained, either 0.25 mg/hr (enalaprilat group, n = 20) or saline solution as placebo (control group, n = 20) was continuously given and continued throughout the following 5 days. Measurements and Main Results Extensive hemodynamic monitoring was carried out in all patients. Plasma concentrations of endothelin-1, angiotensin II, soluble thrombomodulin, and soluble adhesion molecules (endothelial leukocyte adhesion molecule-1, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and granule membrane protein-140) were measured from arterial blood samples. All measurements were carried out before the start of the infusion (baseline values) and daily during the following 5 days. All endothelial-derived substances (thrombomodulin, endothelin-1, and all soluble adhesion molecules) were similarly increased beyond normal in both group. Endothelin-1 increased only in the untreated control patients (from 6.9 +/- 0.7 to 14.3 +/- 1.4 mg/mL). Soluble thrombomodulin increased in the untreated control patients (from 58 +/- 9 to 79 +/- 14 ng/mL [p<.05]), but significantly decreased in the enalaprilat-treated patients. Soluble adhesion molecules increased in the untreated control group (endothelial leukocyte adhesion molecule from 92 +/- 14 to 192 +/- 29 ng/mL; intercellular adhesion molecule-1 from 480 +/- 110 to 850 +/- 119 ng/mL) and returned almost to normal values in the enalaprllat patients. The survival rate did not differ significantly between the two groups. Control patients developed severe sepsis and septic shock more often than the enalaprilat-treated group. Conclusions The complex pathogenesis of endothelial function abnormalities in sepsis may offer a large number of pharmacologic interventions. Administration of the angiotensin-converting enzyme inhibitor enalaprllat resulted in a reduced release of soluble endothelial-derived substances into the circulating blood, which may indicate an improved endothelial function. The specific actions of enalaprilat on the endothelium have to be elucidated in further studies. (Crit Care Med 1998; 26:1663-1670)" @default.
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- W1966295909 date "1998-10-01" @default.
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- W1966295909 title "Influence of angiotensin-converting enzyme inhibitor enalaprilat on endothelial-derived substances in the critically ill" @default.
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- W1966295909 doi "https://doi.org/10.1097/00003246-199810000-00018" @default.
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