FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966297218> ?p ?o ?g. }

• W1966297218 endingPage "229" @default.
• W1966297218 startingPage "220" @default.
• W1966297218 abstract "•Tissue specificity of DNA repair is not well understood and is understudied. •TNR instability is ideal to study DNA repair in different tissues. •Chromatin, repair rates, and protein levels may account for this tissue specificity. •System-level experiments will improve understanding of tissue-specific DNA repair. DNA must constantly be repaired to maintain genome stability. Although it is clear that DNA repair reactions depend on cell type and developmental stage, we know surprisingly little about the mechanisms that underlie this tissue specificity. This is due, in part, to the lack of adequate study systems. This review discusses recent progress toward understanding the mechanism leading to varying rates of instability at expanded trinucleotide repeats (TNRs) in different tissues. Although they are not DNA lesions, TNRs are hotspots for genome instability because normal DNA repair activities cause changes in repeat length. The rates of expansions and contractions are readily detectable and depend on cell identity, making TNR instability a particularly convenient model system. A better understanding of this type of genome instability will provide a foundation for studying tissue-specific DNA repair more generally, which has implications in cancer and other diseases caused by mutations in the caretakers of the genome. DNA must constantly be repaired to maintain genome stability. Although it is clear that DNA repair reactions depend on cell type and developmental stage, we know surprisingly little about the mechanisms that underlie this tissue specificity. This is due, in part, to the lack of adequate study systems. This review discusses recent progress toward understanding the mechanism leading to varying rates of instability at expanded trinucleotide repeats (TNRs) in different tissues. Although they are not DNA lesions, TNRs are hotspots for genome instability because normal DNA repair activities cause changes in repeat length. The rates of expansions and contractions are readily detectable and depend on cell identity, making TNR instability a particularly convenient model system. A better understanding of this type of genome instability will provide a foundation for studying tissue-specific DNA repair more generally, which has implications in cancer and other diseases caused by mutations in the caretakers of the genome." @default.
• W1966297218 created "2016-06-24" @default.
• W1966297218 creator A5084217433 @default.
• W1966297218 date "2014-06-01" @default.
• W1966297218 modified "2023-10-16" @default.
• W1966297218 title "Tissue specificity in DNA repair: lessons from trinucleotide repeat instability" @default.
• W1966297218 cites W1522901791 @default.
• W1966297218 cites W1536477417 @default.
• W1966297218 cites W1561540396 @default.
• W1966297218 cites W1912177776 @default.
• W1966297218 cites W1915898378 @default.
• W1966297218 cites W1964549838 @default.
• W1966297218 cites W1969451832 @default.
• W1966297218 cites W1970814720 @default.
• W1966297218 cites W1973631828 @default.
• W1966297218 cites W1985173578 @default.
• W1966297218 cites W1989365498 @default.
• W1966297218 cites W1990288633 @default.
• W1966297218 cites W1991720664 @default.
• W1966297218 cites W1992859192 @default.
• W1966297218 cites W1993925622 @default.
• W1966297218 cites W1997826732 @default.
• W1966297218 cites W1998576466 @default.
• W1966297218 cites W2000559850 @default.
• W1966297218 cites W2001372713 @default.
• W1966297218 cites W2002938757 @default.
• W1966297218 cites W2004257622 @default.
• W1966297218 cites W2006764478 @default.
• W1966297218 cites W2008489452 @default.
• W1966297218 cites W2015181216 @default.
• W1966297218 cites W2015786741 @default.
• W1966297218 cites W2016097940 @default.
• W1966297218 cites W2017772556 @default.
• W1966297218 cites W2023627547 @default.
• W1966297218 cites W2024357446 @default.
• W1966297218 cites W2025327704 @default.
• W1966297218 cites W2025603881 @default.
• W1966297218 cites W2026504273 @default.
• W1966297218 cites W2026709638 @default.
• W1966297218 cites W2026802661 @default.
• W1966297218 cites W2026815183 @default.
• W1966297218 cites W2026895762 @default.
• W1966297218 cites W2027474410 @default.
• W1966297218 cites W2029777559 @default.
• W1966297218 cites W2037606715 @default.
• W1966297218 cites W2043101035 @default.
• W1966297218 cites W2046082575 @default.
• W1966297218 cites W2051139983 @default.
• W1966297218 cites W2052142634 @default.
• W1966297218 cites W2053077867 @default.
• W1966297218 cites W2053187937 @default.
• W1966297218 cites W2057211837 @default.
• W1966297218 cites W2057586248 @default.
• W1966297218 cites W2062682951 @default.
• W1966297218 cites W2067951632 @default.
• W1966297218 cites W2073315036 @default.
• W1966297218 cites W2074536099 @default.
• W1966297218 cites W2074836283 @default.
• W1966297218 cites W2078477757 @default.
• W1966297218 cites W2078710187 @default.
• W1966297218 cites W2082139407 @default.
• W1966297218 cites W2085155163 @default.
• W1966297218 cites W2092574488 @default.
• W1966297218 cites W2093048712 @default.
• W1966297218 cites W2096331487 @default.
• W1966297218 cites W2106057425 @default.
• W1966297218 cites W2107416433 @default.
• W1966297218 cites W2110139956 @default.
• W1966297218 cites W2111045117 @default.
• W1966297218 cites W2112888760 @default.
• W1966297218 cites W2113189443 @default.
• W1966297218 cites W2113194569 @default.
• W1966297218 cites W2113629413 @default.
• W1966297218 cites W2118572533 @default.
• W1966297218 cites W2122677203 @default.
• W1966297218 cites W2123241821 @default.
• W1966297218 cites W2123702933 @default.
• W1966297218 cites W2125442413 @default.
• W1966297218 cites W2126149307 @default.
• W1966297218 cites W2126254109 @default.
• W1966297218 cites W2126456755 @default.
• W1966297218 cites W2128605862 @default.
• W1966297218 cites W2128909466 @default.
• W1966297218 cites W2131173813 @default.
• W1966297218 cites W2131325142 @default.
• W1966297218 cites W2131418908 @default.
• W1966297218 cites W2134259738 @default.
• W1966297218 cites W2136218435 @default.
• W1966297218 cites W2139715372 @default.
• W1966297218 cites W2140752483 @default.
• W1966297218 cites W2140758998 @default.
• W1966297218 cites W2144540030 @default.
• W1966297218 cites W2145506826 @default.
• W1966297218 cites W2146338810 @default.
• W1966297218 cites W2148649115 @default.
• W1966297218 cites W2150727477 @default.
• W1966297218 cites W2152061559 @default.
• W1966297218 cites W2153430850 @default.

• next