FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966297871> ?p ?o ?g. }

• W1966297871 endingPage "216" @default.
• W1966297871 startingPage "203" @default.
• W1966297871 abstract "The completion of the Human Genome Project aroused renewed interest in alternative splicing, an efficient and widespread mechanism that generates multiple protein isoforms from individual genes. Although our knowledge about alternative splicing is growing exponentially, its real impact on cellular life is still to be clarified. Connecting all splicing features (genes, splice transcripts, isoforms, and relative functions) may be useful to resolve this tangle. Herein, we will start from the case of a single gene, Parkinson protein 2, E3 ubiquitin protein ligase (PARK2), one of the largest in our genome. This gene is implicated in the pathogenesis of autosomal recessive juvenile Parkinsonism and it has been recently linked to cancer, leprosy, autism, type 2 diabetes mellitus and Alzheimer's disease. PARK2 primary transcript undergoes an extensive alternative splicing, which enhances transcriptomic diversification and protein diversity in tissues and cells. This review will provide an update of all human PARK2 alternative splice transcripts and isoforms presently known, and correlate them to those in rat and mouse, two common animal models for studying human disease genes. Alternative splicing relies upon a complex process that could be easily altered by both cis and trans-acting mutations. Although the contribution of PARK2 splicing in human disease remains to be fully explored, some evidences show disruption of this versatile form of genetic regulation may have pathological consequences." @default.
• W1966297871 created "2016-06-24" @default.
• W1966297871 creator A5001875483 @default.
• W1966297871 creator A5002653291 @default.
• W1966297871 creator A5034216940 @default.
• W1966297871 creator A5034551230 @default.
• W1966297871 creator A5049723953 @default.
• W1966297871 creator A5054803296 @default.
• W1966297871 creator A5061501713 @default.
• W1966297871 date "2014-06-01" @default.
• W1966297871 modified "2023-10-03" @default.
• W1966297871 title "Increasing the Coding Potential of Genomes Through Alternative Splicing: The Case of PARK2 Gene" @default.
• W1966297871 cites W1877873625 @default.
• W1966297871 cites W1965754678 @default.
• W1966297871 cites W1966157852 @default.
• W1966297871 cites W1980477780 @default.
• W1966297871 cites W1987367583 @default.
• W1966297871 cites W1990048226 @default.
• W1966297871 cites W2005406723 @default.
• W1966297871 cites W2008005122 @default.
• W1966297871 cites W2008025085 @default.
• W1966297871 cites W2011513822 @default.
• W1966297871 cites W2011894009 @default.
• W1966297871 cites W2012284471 @default.
• W1966297871 cites W2014433557 @default.
• W1966297871 cites W2014459126 @default.
• W1966297871 cites W2019185025 @default.
• W1966297871 cites W2020078753 @default.
• W1966297871 cites W2023506303 @default.
• W1966297871 cites W2027484924 @default.
• W1966297871 cites W2027574361 @default.
• W1966297871 cites W2032124374 @default.
• W1966297871 cites W2035799305 @default.
• W1966297871 cites W2037939374 @default.
• W1966297871 cites W2045131720 @default.
• W1966297871 cites W2045147326 @default.
• W1966297871 cites W2045277217 @default.
• W1966297871 cites W2049957807 @default.
• W1966297871 cites W2055159698 @default.
• W1966297871 cites W2061053402 @default.
• W1966297871 cites W2067838228 @default.
• W1966297871 cites W2069271383 @default.
• W1966297871 cites W2069403245 @default.
• W1966297871 cites W2073062083 @default.
• W1966297871 cites W2074344122 @default.
• W1966297871 cites W2076512990 @default.
• W1966297871 cites W2077611349 @default.
• W1966297871 cites W2077689651 @default.
• W1966297871 cites W2078506790 @default.
• W1966297871 cites W2079104114 @default.
• W1966297871 cites W2079700496 @default.
• W1966297871 cites W2086557228 @default.
• W1966297871 cites W2088962120 @default.
• W1966297871 cites W2089910117 @default.
• W1966297871 cites W2095236729 @default.
• W1966297871 cites W2102136953 @default.
• W1966297871 cites W2103959926 @default.
• W1966297871 cites W2105402655 @default.
• W1966297871 cites W2105810043 @default.
• W1966297871 cites W2110987512 @default.
• W1966297871 cites W2116229231 @default.
• W1966297871 cites W2117335809 @default.
• W1966297871 cites W2124914823 @default.
• W1966297871 cites W2129698492 @default.
• W1966297871 cites W2130303726 @default.
• W1966297871 cites W2138944318 @default.
• W1966297871 cites W2139056264 @default.
• W1966297871 cites W2139638246 @default.
• W1966297871 cites W2145683656 @default.
• W1966297871 cites W2146535845 @default.
• W1966297871 cites W2148886011 @default.
• W1966297871 cites W2150717653 @default.
• W1966297871 cites W2151462466 @default.
• W1966297871 cites W2158259597 @default.
• W1966297871 cites W2158511243 @default.
• W1966297871 cites W2160620582 @default.
• W1966297871 cites W2317804643 @default.
• W1966297871 cites W2099708534 @default.
• W1966297871 doi "https://doi.org/10.2174/1389202915666140426003342" @default.
• W1966297871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4064560" @default.
• W1966297871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24955028" @default.
• W1966297871 hasPublicationYear "2014" @default.
• W1966297871 type Work @default.
• W1966297871 sameAs 1966297871 @default.
• W1966297871 citedByCount "32" @default.
• W1966297871 countsByYear W19662978712014 @default.
• W1966297871 countsByYear W19662978712015 @default.
• W1966297871 countsByYear W19662978712016 @default.
• W1966297871 countsByYear W19662978712017 @default.
• W1966297871 countsByYear W19662978712018 @default.
• W1966297871 countsByYear W19662978712020 @default.
• W1966297871 countsByYear W19662978712021 @default.
• W1966297871 countsByYear W19662978712022 @default.
• W1966297871 countsByYear W19662978712023 @default.
• W1966297871 crossrefType "journal-article" @default.
• W1966297871 hasAuthorship W1966297871A5001875483 @default.
• W1966297871 hasAuthorship W1966297871A5002653291 @default.
• W1966297871 hasAuthorship W1966297871A5034216940 @default.

• next