FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966298313> ?p ?o ?g. }

• W1966298313 endingPage "137" @default.
• W1966298313 startingPage "129" @default.
• W1966298313 abstract "Bisphenol A (BPA), an environmental endocrine disruptor, has attracted increasing attention to its adverse effects on brain developmental process. The previous study indicated that BPA rapidly increased motility and density of dendritic filopodia and enhanced the phosphorylation of N-methyl-d-aspartate (NMDA) receptor subunit NR2B in cultured hippocampal neurons within 30 min. The purpose of the present study was further to investigate the effects of BPA for 24 h on dendritic morphogenesis and the underlying mechanisms. After cultured for 5 d in vitro, the hippocampal neurons from 24 h-old rat were infected by AdV-EGFP to indicate time-lapse imaging of living neurons. The results demonstrated that the exposure of the cultured hippocampal neurons to BPA (10, 100 nM) or 17β-estradiol (17β-E2, 10 nM) for 24 h significantly promoted dendritic development, as evidenced by the increased total length of dendrite and the enhanced motility and density of dendritic filopodia. However, these changes were suppressed by an ERs antagonist, ICI182,780, a non-competitive NMDA receptor antagonist, MK-801, and a mitogen-activated ERK1/2-activating kinase (MEK1/2) inhibitor, U0126. Meanwhile, the increased F-actin (filamentous actin) induced by BPA (100 nM) was also completely eliminated by these blockers. Furthermore, the result of western blot analyses showed that, the exposure of the cultures to BPA or 17β-E2 for 24 h promoted the expression of Rac1/Cdc42 but inhibited that of RhoA, suggesting Rac1 (Ras related C3 botulinum toxinsubstrate 1)/Cdc42 (cell divisioncycle 42) and RhoA (Ras homologous A), the Rho family of small GTPases, were involved in BPA- or 17β-E2-induced changes in the dendritic morphogenesis of neurons. These BPA- or 17β-E2-induced effects were completely blocked by ICI182,780, and were partially suppressed by U0126. These results reveal that, similar to 17β-E2, BPA exerts its effects on dendritic morphogenesis by eliciting both nuclear actions and extranuclear-initiated actions that are integrated to influence the development of dendrite in hippocampal neurons." @default.
• W1966298313 created "2016-06-24" @default.
• W1966298313 creator A5006869577 @default.
• W1966298313 creator A5010738468 @default.
• W1966298313 creator A5016726646 @default.
• W1966298313 creator A5023851808 @default.
• W1966298313 creator A5052913645 @default.
• W1966298313 creator A5057105526 @default.
• W1966298313 creator A5076822031 @default.
• W1966298313 creator A5085737767 @default.
• W1966298313 date "2014-02-01" @default.
• W1966298313 modified "2023-09-26" @default.
• W1966298313 title "Bisphenol A promotes dendritic morphogenesis of hippocampal neurons through estrogen receptor-mediated ERK1/2 signal pathway" @default.
• W1966298313 cites W1677457722 @default.
• W1966298313 cites W1834463603 @default.
• W1966298313 cites W1965670425 @default.
• W1966298313 cites W1978528899 @default.
• W1966298313 cites W1980383923 @default.
• W1966298313 cites W1983553517 @default.
• W1966298313 cites W1985323921 @default.
• W1966298313 cites W1985839684 @default.
• W1966298313 cites W1990651762 @default.
• W1966298313 cites W1995946234 @default.
• W1966298313 cites W1998046189 @default.
• W1966298313 cites W1999724177 @default.
• W1966298313 cites W2003534575 @default.
• W1966298313 cites W2005189358 @default.
• W1966298313 cites W2006252312 @default.
• W1966298313 cites W2006969689 @default.
• W1966298313 cites W2014782509 @default.
• W1966298313 cites W2017577062 @default.
• W1966298313 cites W2022190561 @default.
• W1966298313 cites W2028135977 @default.
• W1966298313 cites W2033087539 @default.
• W1966298313 cites W2036103642 @default.
• W1966298313 cites W2038761368 @default.
• W1966298313 cites W2040653138 @default.
• W1966298313 cites W2045499624 @default.
• W1966298313 cites W2045824781 @default.
• W1966298313 cites W2047446272 @default.
• W1966298313 cites W2052796543 @default.
• W1966298313 cites W2053010338 @default.
• W1966298313 cites W2054366304 @default.
• W1966298313 cites W2056736352 @default.
• W1966298313 cites W2057188343 @default.
• W1966298313 cites W2064854818 @default.
• W1966298313 cites W2065847146 @default.
• W1966298313 cites W2079724894 @default.
• W1966298313 cites W2079956982 @default.
• W1966298313 cites W2085280717 @default.
• W1966298313 cites W2087133395 @default.
• W1966298313 cites W2087330484 @default.
• W1966298313 cites W2090850820 @default.
• W1966298313 cites W2094455233 @default.
• W1966298313 cites W2103762808 @default.
• W1966298313 cites W2108215229 @default.
• W1966298313 cites W2109282960 @default.
• W1966298313 cites W2116144731 @default.
• W1966298313 cites W2121403142 @default.
• W1966298313 cites W2126761857 @default.
• W1966298313 cites W2148013477 @default.
• W1966298313 cites W2151843908 @default.
• W1966298313 cites W2157029495 @default.
• W1966298313 cites W2169726583 @default.
• W1966298313 cites W2171612971 @default.
• W1966298313 doi "https://doi.org/10.1016/j.chemosphere.2013.09.063" @default.
• W1966298313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24231043" @default.
• W1966298313 hasPublicationYear "2014" @default.
• W1966298313 type Work @default.
• W1966298313 sameAs 1966298313 @default.
• W1966298313 citedByCount "40" @default.
• W1966298313 countsByYear W19662983132014 @default.
• W1966298313 countsByYear W19662983132015 @default.
• W1966298313 countsByYear W19662983132016 @default.
• W1966298313 countsByYear W19662983132017 @default.
• W1966298313 countsByYear W19662983132018 @default.
• W1966298313 countsByYear W19662983132019 @default.
• W1966298313 countsByYear W19662983132020 @default.
• W1966298313 countsByYear W19662983132021 @default.
• W1966298313 countsByYear W19662983132022 @default.
• W1966298313 countsByYear W19662983132023 @default.
• W1966298313 crossrefType "journal-article" @default.
• W1966298313 hasAuthorship W1966298313A5006869577 @default.
• W1966298313 hasAuthorship W1966298313A5010738468 @default.
• W1966298313 hasAuthorship W1966298313A5016726646 @default.
• W1966298313 hasAuthorship W1966298313A5023851808 @default.
• W1966298313 hasAuthorship W1966298313A5052913645 @default.
• W1966298313 hasAuthorship W1966298313A5057105526 @default.
• W1966298313 hasAuthorship W1966298313A5076822031 @default.
• W1966298313 hasAuthorship W1966298313A5085737767 @default.
• W1966298313 hasConcept C121608353 @default.
• W1966298313 hasConcept C125705527 @default.
• W1966298313 hasConcept C134018914 @default.
• W1966298313 hasConcept C148762608 @default.
• W1966298313 hasConcept C170493617 @default.
• W1966298313 hasConcept C174884520 @default.
• W1966298313 hasConcept C184235292 @default.
• W1966298313 hasConcept C185592680 @default.

• next