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• W1966302803 abstract "DNA-binding proteins are of utmost importance to gene regulation. The identification of DNA-binding domains is useful for understanding the regulation mechanisms of DNA-binding proteins. In this study, we proposed a method to determine whether a domain or a protein can has DNA binding capability by considering evolutionary conservation of DNA-binding residues. Our method achieves high precision and recall for 66 families of DNA-binding domains, with a false positive rate less than 5% for 250 non-DNA-binding proteins. In addition, experimental results show that our method is able to identify the different DNA-binding behaviors of proteins in the same SCOP family based on the use of evolutionary conservation of DNA-contact residues." @default.
• W1966302803 created "2016-06-24" @default.
• W1966302803 creator A5014514590 @default.
• W1966302803 creator A5079257898 @default.
• W1966302803 date "2007-08-01" @default.
• W1966302803 modified "2023-09-25" @default.
• W1966302803 title "Evolutionary conservation of DNA-contact residues in DNA-binding domains" @default.
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• W1966302803 doi "https://doi.org/10.1109/imsccs.2007.24" @default.
• W1966302803 hasPublicationYear "2007" @default.
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