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- W1966303173 abstract "μ-receptor affinities have been determined for a number of opioid drugs using a combination of isolated tissue and receptor binding techniques. The affinities of antagonists and partial agonists were determined by their ability to antagonise responses to [D-Ala2, MePhe4, Glyol5]enkephalin (GLYOL) on the rat vas deferens preparation. There was little correlation between these results and affinities measured by displacement of [3H]-GLYOL from guinea-pig brain membranes incubated in 50mM Tris buffer. By contrast, affinities measured by displacement of [3H]-naloxone from rat brain membranes incubated in a KrebsHEPES buffer containing a non-hydrolysable analogue of GTP, agreed very closely with the isolated tissue data." @default.
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- W1966303173 date "1984-12-01" @default.
- W1966303173 modified "2023-09-25" @default.
- W1966303173 title "Mu-receptor binding in physiological media: Comparison with isolated tissue data" @default.
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- W1966303173 doi "https://doi.org/10.1016/0143-4179(84)90034-9" @default.
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