FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966304212> ?p ?o ?g. }

• W1966304212 endingPage "76" @default.
• W1966304212 startingPage "72" @default.
• W1966304212 abstract "Previous studies have shown that with prophylactic colchicine 65% of the patients suffering from Familial Mediterranean fever (FMF) will show a complete response, 30% a partial response and about 5% will show minimum or no response. These studies were performed before the isolation of the disease gene. Genotyping enables us to study the response rates according to specific mutations. We have witnessed a large number of M694V homozygotes who do not respond well to colchicine despite being treated with maximal sustained doses.To assess the response rates to colchicine in M694V homozygote FMF patients in comparison to other prevalent genotypes.We conducted a telephonic survey which included 112 FMF patients: 40 M694V homozygotes, and 2 comparison groups of 41 M694V/V726A compound heterozygotes and 31 V726A homozygotes. The questionnaire included demographic, social and clinical features, colchicine dose, response rates and reported side effects.M694 homozygotes showed a more severe disease, and were treated with higher doses of colchicine (average dose 1.98±0.56 compared to 1.47±0.58, p=0.0001 and 1.13±0.41, p<0.001 in the M694V/V726A compound heterozygotes and the V726A homozygotes, respectively); Colchicine related side effects were noted in 40% of the M694V homozygotes. The average rate of attacks in treated M694V homozygotes (0.70±1.06) was higher compared to the two other groups (0.14±0.26, p=0.002 and 0.08±0.20, p=0.0009, respectively) and only 25% of them reported no attacks in the last year. None of the patients who took part in this study had amyloidosis. Side effects limiting the dose of colchicine were noted in 40% of the M694V homozygotes.Despite receiving higher doses of colchicine the prevalence of complete responders among M694V homozygotes is much lower than previously appreciated. The results highlight the need for additional treatment modalities for these patients." @default.
• W1966304212 created "2016-06-24" @default.
• W1966304212 creator A5009083689 @default.
• W1966304212 creator A5016753379 @default.
• W1966304212 creator A5025700190 @default.
• W1966304212 creator A5033360069 @default.
• W1966304212 creator A5062880946 @default.
• W1966304212 creator A5069426754 @default.
• W1966304212 creator A5081816318 @default.
• W1966304212 creator A5086731063 @default.
• W1966304212 date "2012-11-01" @default.
• W1966304212 modified "2023-09-30" @default.
• W1966304212 title "Incomplete response to colchicine in M694V homozygote FMF patients" @default.
• W1966304212 cites W1966674697 @default.
• W1966304212 cites W1971808760 @default.
• W1966304212 cites W1980103460 @default.
• W1966304212 cites W1980442164 @default.
• W1966304212 cites W2002529218 @default.
• W1966304212 cites W2016935631 @default.
• W1966304212 cites W2035113730 @default.
• W1966304212 cites W2048982572 @default.
• W1966304212 cites W2052886925 @default.
• W1966304212 cites W2069204993 @default.
• W1966304212 cites W2092264647 @default.
• W1966304212 cites W2095834327 @default.
• W1966304212 cites W2105232821 @default.
• W1966304212 cites W2108558214 @default.
• W1966304212 cites W2112259768 @default.
• W1966304212 cites W2137599929 @default.
• W1966304212 cites W2137680090 @default.
• W1966304212 cites W2242165656 @default.
• W1966304212 cites W2325631708 @default.
• W1966304212 cites W4251129201 @default.
• W1966304212 doi "https://doi.org/10.1016/j.autrev.2012.07.025" @default.
• W1966304212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22884555" @default.
• W1966304212 hasPublicationYear "2012" @default.
• W1966304212 type Work @default.
• W1966304212 sameAs 1966304212 @default.
• W1966304212 citedByCount "63" @default.
• W1966304212 countsByYear W19663042122012 @default.
• W1966304212 countsByYear W19663042122013 @default.
• W1966304212 countsByYear W19663042122014 @default.
• W1966304212 countsByYear W19663042122015 @default.
• W1966304212 countsByYear W19663042122016 @default.
• W1966304212 countsByYear W19663042122017 @default.
• W1966304212 countsByYear W19663042122018 @default.
• W1966304212 countsByYear W19663042122019 @default.
• W1966304212 countsByYear W19663042122020 @default.
• W1966304212 countsByYear W19663042122021 @default.
• W1966304212 countsByYear W19663042122022 @default.
• W1966304212 countsByYear W19663042122023 @default.
• W1966304212 crossrefType "journal-article" @default.
• W1966304212 hasAuthorship W1966304212A5009083689 @default.
• W1966304212 hasAuthorship W1966304212A5016753379 @default.
• W1966304212 hasAuthorship W1966304212A5025700190 @default.
• W1966304212 hasAuthorship W1966304212A5033360069 @default.
• W1966304212 hasAuthorship W1966304212A5062880946 @default.
• W1966304212 hasAuthorship W1966304212A5069426754 @default.
• W1966304212 hasAuthorship W1966304212A5081816318 @default.
• W1966304212 hasAuthorship W1966304212A5086731063 @default.
• W1966304212 hasConcept C104317684 @default.
• W1966304212 hasConcept C12125453 @default.
• W1966304212 hasConcept C126322002 @default.
• W1966304212 hasConcept C135763542 @default.
• W1966304212 hasConcept C153471976 @default.
• W1966304212 hasConcept C180754005 @default.
• W1966304212 hasConcept C2776636253 @default.
• W1966304212 hasConcept C2779134260 @default.
• W1966304212 hasConcept C2779537928 @default.
• W1966304212 hasConcept C31467283 @default.
• W1966304212 hasConcept C54355233 @default.
• W1966304212 hasConcept C71924100 @default.
• W1966304212 hasConcept C86803240 @default.
• W1966304212 hasConcept C90924648 @default.
• W1966304212 hasConceptScore W1966304212C104317684 @default.
• W1966304212 hasConceptScore W1966304212C12125453 @default.
• W1966304212 hasConceptScore W1966304212C126322002 @default.
• W1966304212 hasConceptScore W1966304212C135763542 @default.
• W1966304212 hasConceptScore W1966304212C153471976 @default.
• W1966304212 hasConceptScore W1966304212C180754005 @default.
• W1966304212 hasConceptScore W1966304212C2776636253 @default.
• W1966304212 hasConceptScore W1966304212C2779134260 @default.
• W1966304212 hasConceptScore W1966304212C2779537928 @default.
• W1966304212 hasConceptScore W1966304212C31467283 @default.
• W1966304212 hasConceptScore W1966304212C54355233 @default.
• W1966304212 hasConceptScore W1966304212C71924100 @default.
• W1966304212 hasConceptScore W1966304212C86803240 @default.
• W1966304212 hasConceptScore W1966304212C90924648 @default.
• W1966304212 hasIssue "1" @default.
• W1966304212 hasLocation W19663042121 @default.
• W1966304212 hasLocation W19663042122 @default.
• W1966304212 hasOpenAccess W1966304212 @default.
• W1966304212 hasPrimaryLocation W19663042121 @default.
• W1966304212 hasRelatedWork W1916386404 @default.
• W1966304212 hasRelatedWork W1951926033 @default.
• W1966304212 hasRelatedWork W2034745432 @default.
• W1966304212 hasRelatedWork W2085511279 @default.
• W1966304212 hasRelatedWork W2095070094 @default.

• next