Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966309110> ?p ?o ?g. }
- W1966309110 endingPage "36" @default.
- W1966309110 startingPage "28" @default.
- W1966309110 abstract "In view of the bioinformatic projection that a third of all protein coding genes and essentially all biological pathways are under control of microRNAs (miRNAs), it is not surprising that this class of small RNAs plays roles in vascular disease progression. MiRNAs have been shown to be involved in cholesterol turnover, thrombosis, glucose homeostasis and vascular function. Some miRNAs appear to be specific for certain cells, and the role that such cell-specific miRNAs play in vascular disease is only beginning to be appreciated. A notable example is the miR-143/145 cluster which is enriched in mature and highly differentiated smooth muscle cells (SMCs). Here we outline and discuss the recent literature on SMC-expressed miRNAs in major vascular diseases, including atherosclerosis, neointima formation, aortic aneurysm formation, and pulmonary arterial hypertension. Forced expression of miR-145 emerges as a promising strategy for reduction and stabilization of atherosclerotic plaques as well as for reducing neointimal hyperplasia. It is concluded that if obstacles in the form of delivery and untoward effects of antimirs and mimics can be overcome, the outlook for targeting of SMC-specific miRNAs for therapeutic benefit in vascular disease is bright." @default.
- W1966309110 created "2016-06-24" @default.
- W1966309110 creator A5000951686 @default.
- W1966309110 creator A5006983556 @default.
- W1966309110 date "2013-09-01" @default.
- W1966309110 modified "2023-09-27" @default.
- W1966309110 title "Targeting smooth muscle microRNAs for therapeutic benefit in vascular disease" @default.
- W1966309110 cites W1606441445 @default.
- W1966309110 cites W1838133438 @default.
- W1966309110 cites W1854830079 @default.
- W1966309110 cites W1965030833 @default.
- W1966309110 cites W1965482714 @default.
- W1966309110 cites W1976016129 @default.
- W1966309110 cites W1978208518 @default.
- W1966309110 cites W1981168111 @default.
- W1966309110 cites W1986147677 @default.
- W1966309110 cites W1988350401 @default.
- W1966309110 cites W1989433466 @default.
- W1966309110 cites W1989910375 @default.
- W1966309110 cites W1990347775 @default.
- W1966309110 cites W1996630410 @default.
- W1966309110 cites W1997524334 @default.
- W1966309110 cites W1999792045 @default.
- W1966309110 cites W1999812198 @default.
- W1966309110 cites W1999943971 @default.
- W1966309110 cites W2000456938 @default.
- W1966309110 cites W2005406090 @default.
- W1966309110 cites W2005889517 @default.
- W1966309110 cites W2009872881 @default.
- W1966309110 cites W2014154760 @default.
- W1966309110 cites W2014346055 @default.
- W1966309110 cites W2017027000 @default.
- W1966309110 cites W2018621592 @default.
- W1966309110 cites W2018804632 @default.
- W1966309110 cites W2022022817 @default.
- W1966309110 cites W2026547930 @default.
- W1966309110 cites W2027138842 @default.
- W1966309110 cites W2030036124 @default.
- W1966309110 cites W2030079958 @default.
- W1966309110 cites W2031529022 @default.
- W1966309110 cites W2037141618 @default.
- W1966309110 cites W2038464067 @default.
- W1966309110 cites W2044762564 @default.
- W1966309110 cites W2046372092 @default.
- W1966309110 cites W2047493201 @default.
- W1966309110 cites W2052402508 @default.
- W1966309110 cites W2053146170 @default.
- W1966309110 cites W2060737779 @default.
- W1966309110 cites W2065678878 @default.
- W1966309110 cites W2067561562 @default.
- W1966309110 cites W2069629141 @default.
- W1966309110 cites W2072190764 @default.
- W1966309110 cites W2075046191 @default.
- W1966309110 cites W2075317528 @default.
- W1966309110 cites W2075728036 @default.
- W1966309110 cites W2079245209 @default.
- W1966309110 cites W2079465506 @default.
- W1966309110 cites W2082604867 @default.
- W1966309110 cites W2082893668 @default.
- W1966309110 cites W2083010238 @default.
- W1966309110 cites W2083364674 @default.
- W1966309110 cites W2085185881 @default.
- W1966309110 cites W2086545594 @default.
- W1966309110 cites W2092842296 @default.
- W1966309110 cites W2093374499 @default.
- W1966309110 cites W2094644076 @default.
- W1966309110 cites W2094940134 @default.
- W1966309110 cites W2096166765 @default.
- W1966309110 cites W2102010919 @default.
- W1966309110 cites W2102569350 @default.
- W1966309110 cites W2103680698 @default.
- W1966309110 cites W2104584146 @default.
- W1966309110 cites W2107878130 @default.
- W1966309110 cites W2108157464 @default.
- W1966309110 cites W2108661174 @default.
- W1966309110 cites W2110990055 @default.
- W1966309110 cites W2112137254 @default.
- W1966309110 cites W2112848098 @default.
- W1966309110 cites W2112892927 @default.
- W1966309110 cites W2115667151 @default.
- W1966309110 cites W2117307038 @default.
- W1966309110 cites W2120156784 @default.
- W1966309110 cites W2122455142 @default.
- W1966309110 cites W2128940917 @default.
- W1966309110 cites W2130330362 @default.
- W1966309110 cites W2131736566 @default.
- W1966309110 cites W2132762707 @default.
- W1966309110 cites W2135613885 @default.
- W1966309110 cites W2135742242 @default.
- W1966309110 cites W2137122654 @default.
- W1966309110 cites W2139342290 @default.
- W1966309110 cites W2144360877 @default.
- W1966309110 cites W2145244713 @default.
- W1966309110 cites W2145988292 @default.
- W1966309110 cites W2146104000 @default.
- W1966309110 cites W2146684369 @default.
- W1966309110 cites W2146917818 @default.
- W1966309110 cites W2149258710 @default.