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- W1966311917 abstract "Significance It is known that the gastrointestinal microbiota influences adiposity and weight gain in the host. However the mechanisms by which gut microorganisms coordinate host physiological processes are currently unclear. We demonstrate that a single, widely distributed function of the gut microbiota, bile salt hydrolase (BSH) activity, significantly influences lipid metabolism, weight gain, and cholesterol levels in the host. In our study microbial BSH activity was shown to direct expression of host signalling pathways with known roles in lipid metabolism, circadian rhythm, and epithelial cell function. The work defines the significant impact of in situ bile hydrolysis on host metabolism and indicates how this finding may be exploited as a potential intervention strategy for the control of obesity and metabolic syndrome." @default.
- W1966311917 created "2016-06-24" @default.
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- W1966311917 date "2014-05-05" @default.
- W1966311917 modified "2023-10-18" @default.
- W1966311917 title "Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut" @default.
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- W1966311917 doi "https://doi.org/10.1073/pnas.1323599111" @default.
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