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• W1966331369 endingPage "178" @default.
• W1966331369 startingPage "167" @default.
• W1966331369 abstract "Acrylamide, a known male postmeiotic germ cell mutagen, caused a dose-dependent increase in the frequency of morphologic abnormalities in preimplantation embryos. Single-cell eggs, growth retardation, and blastomere lysis were detected after paternal treatment with acrylamide (10 to 50 mg/kg, 5 d). The major effects were seen at weeks 1 to 3 after male treatment, with the highest level of abnormalities at the first week (> 90% vs. 5% in control). The frequency of abnormal four-day embryos was similar to preimplantation loss assessed at 15 to 16 d p.c. A > 100-fold elevation of chromatin adducts in sperm was observed during 1st and 2nd week after treatment, after which adduct levels decreased to baseline level. However, morphologic defects in embryos are not fully explained by the spermatid adduct curve. These findings demonstrate the effects of paternal exposure to acrylamide on preimplantation development and indicate a potential risk to the offspring of men exposed to acrylamide." @default.
• W1966331369 created "2016-06-24" @default.
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• W1966331369 date "1999-05-01" @default.
• W1966331369 modified "2023-09-27" @default.
• W1966331369 title "Acrylamide causes preimplantation abnormalities in embryos and induces chromatin-adducts in male germ cells of mice" @default.
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• W1966331369 doi "https://doi.org/10.1016/s0890-6238(99)00011-8" @default.
• W1966331369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10378466" @default.
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