FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966332480> ?p ?o ?g. }

• W1966332480 endingPage "584" @default.
• W1966332480 startingPage "575" @default.
• W1966332480 abstract "Radiation therapy (RT) plays a critical role in the local-regional control of head and neck squamous cell carcinoma (HNSCC). However, the efficacy of RT in treating HNSCC is limited by severe normal tissue toxicity, predominantly mucositis. One pharmacological approach for increasing the clinical response to RT is the use of radiation response modifiers that preferentially sensitize tumor cells. Previously we demonstrated that curcumin, a natural plant polyphenol, increased the radiation sensitivity of HNSCC cells and that the observed sensitization was dependent on curcumin-mediated inhibition of thioredoxin reductase 1 (TxnRd1) a key cytosolic regulator of redox-dependent signaling. Here, we examined curcumin-induced radiation sensitization in HNSCC cell lines with differing HPV status and expressing different levels of TxnRd1, in vitro. The intrinsic radiation resistance of the HPV (-) cell lines was significantly higher than the HPV (+) cell lines used in our study. Notably, all of the HPV (-) cell lines expressed high levels of TxnRd1 and exhibited higher intrinsic resistance to RT. While curcumin was effective at increasing the radiation response of the resistant HPV (-) cell lines it had no effect on the HPV (+) cells. Based on these findings we employed an orthotopic, HPV (-) HNSCC tumor model in athymic nude mice to examine the effect of combining curcumin with fractionated RT, in vivo. The combination of curcumin feeding and fractionated RT had a significant effect on tumor doubling time and overall animal survival. We therefore propose that curcumin and RT should be considered as a first line treatment of HPV (-) HNSCC." @default.
• W1966332480 created "2016-06-24" @default.
• W1966332480 creator A5009884201 @default.
• W1966332480 creator A5013194098 @default.
• W1966332480 creator A5017743060 @default.
• W1966332480 creator A5017991749 @default.
• W1966332480 creator A5025539061 @default.
• W1966332480 creator A5027030638 @default.
• W1966332480 creator A5057978718 @default.
• W1966332480 creator A5078596837 @default.
• W1966332480 creator A5082730843 @default.
• W1966332480 creator A5082801249 @default.
• W1966332480 date "2012-05-01" @default.
• W1966332480 modified "2023-10-06" @default.
• W1966332480 title "The chemopreventive and clinically used agent curcumin sensitizes HPV^-but not HPV⁺HNSCC to ionizing radiation, in vitro and in a mouse orthotopic model" @default.
• W1966332480 cites W1572408047 @default.
• W1966332480 cites W1604068141 @default.
• W1966332480 cites W1967208836 @default.
• W1966332480 cites W1970745143 @default.
• W1966332480 cites W1972685575 @default.
• W1966332480 cites W1976194786 @default.
• W1966332480 cites W1976971060 @default.
• W1966332480 cites W1980828424 @default.
• W1966332480 cites W1980911765 @default.
• W1966332480 cites W1981657616 @default.
• W1966332480 cites W1990305582 @default.
• W1966332480 cites W1990956554 @default.
• W1966332480 cites W1993295950 @default.
• W1966332480 cites W1996439981 @default.
• W1966332480 cites W1997149430 @default.
• W1966332480 cites W2002462958 @default.
• W1966332480 cites W2016145981 @default.
• W1966332480 cites W2017859884 @default.
• W1966332480 cites W2020061207 @default.
• W1966332480 cites W2020319882 @default.
• W1966332480 cites W2028556682 @default.
• W1966332480 cites W2028696733 @default.
• W1966332480 cites W2033431239 @default.
• W1966332480 cites W2036005555 @default.
• W1966332480 cites W2044574682 @default.
• W1966332480 cites W2047529067 @default.
• W1966332480 cites W2052684594 @default.
• W1966332480 cites W2060763328 @default.
• W1966332480 cites W2061846688 @default.
• W1966332480 cites W2075669667 @default.
• W1966332480 cites W2077008353 @default.
• W1966332480 cites W2077792640 @default.
• W1966332480 cites W2079296486 @default.
• W1966332480 cites W2081519457 @default.
• W1966332480 cites W2090162098 @default.
• W1966332480 cites W2092800030 @default.
• W1966332480 cites W2092803489 @default.
• W1966332480 cites W2094678858 @default.
• W1966332480 cites W2100961085 @default.
• W1966332480 cites W2110664940 @default.
• W1966332480 cites W2111114352 @default.
• W1966332480 cites W2114744780 @default.
• W1966332480 cites W2115494253 @default.
• W1966332480 cites W2116375511 @default.
• W1966332480 cites W2119184505 @default.
• W1966332480 cites W2126530235 @default.
• W1966332480 cites W2129144386 @default.
• W1966332480 cites W2136409533 @default.
• W1966332480 cites W2136740551 @default.
• W1966332480 cites W2137631271 @default.
• W1966332480 cites W2138508372 @default.
• W1966332480 cites W2139348853 @default.
• W1966332480 cites W2145078756 @default.
• W1966332480 cites W2155015510 @default.
• W1966332480 cites W2159179419 @default.
• W1966332480 cites W2172024684 @default.
• W1966332480 cites W2174129045 @default.
• W1966332480 cites W2317541348 @default.
• W1966332480 cites W2886259079 @default.
• W1966332480 doi "https://doi.org/10.4161/cbt.19772" @default.
• W1966332480 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4727515" @default.
• W1966332480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22441776" @default.
• W1966332480 hasPublicationYear "2012" @default.
• W1966332480 type Work @default.
• W1966332480 sameAs 1966332480 @default.
• W1966332480 citedByCount "32" @default.
• W1966332480 countsByYear W19663324802013 @default.
• W1966332480 countsByYear W19663324802014 @default.
• W1966332480 countsByYear W19663324802015 @default.
• W1966332480 countsByYear W19663324802016 @default.
• W1966332480 countsByYear W19663324802017 @default.
• W1966332480 countsByYear W19663324802018 @default.
• W1966332480 countsByYear W19663324802019 @default.
• W1966332480 countsByYear W19663324802020 @default.
• W1966332480 countsByYear W19663324802022 @default.
• W1966332480 countsByYear W19663324802023 @default.
• W1966332480 crossrefType "journal-article" @default.
• W1966332480 hasAuthorship W1966332480A5009884201 @default.
• W1966332480 hasAuthorship W1966332480A5013194098 @default.
• W1966332480 hasAuthorship W1966332480A5017743060 @default.
• W1966332480 hasAuthorship W1966332480A5017991749 @default.
• W1966332480 hasAuthorship W1966332480A5025539061 @default.
• W1966332480 hasAuthorship W1966332480A5027030638 @default.

• next