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- W1966335038 endingPage "2061" @default.
- W1966335038 startingPage "2051" @default.
- W1966335038 abstract "Glutamine is a multifaceted amino acid that plays key roles in many metabolic pathways and also fulfils essential signaling functions. Although classified as non-essential, recent evidence suggests that glutamine is a conditionally essential amino acid in several physiological situations. Glutamine homeostasis must therefore be exquisitely regulated and mitochondria represent a major site of glutamine metabolism in numerous cell types. Glutaminolysis is mostly a mitochondrial process with repercussions in organelle structure and dynamics suggesting a tight and mutual control between mitochondrial form and cell bioenergetics. In this review we describe an updated account focused on the critical involvement of glutamine in oxidative stress, mitochondrial dysfunction and tumour cell proliferation, with special emphasis in the initial steps of mitochondrial glutamine pathways: transport into the organelle and hydrolytic deamidation through glutaminase enzymes. Some controversial issues about glutamine catabolism within mitochondria are also reviewed." @default.
- W1966335038 created "2016-06-24" @default.
- W1966335038 creator A5002088132 @default.
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- W1966335038 creator A5040326530 @default.
- W1966335038 creator A5072494699 @default.
- W1966335038 creator A5075597784 @default.
- W1966335038 date "2009-10-01" @default.
- W1966335038 modified "2023-10-15" @default.
- W1966335038 title "Glutamine homeostasis and mitochondrial dynamics" @default.
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