FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966338375> ?p ?o ?g. }

• W1966338375 endingPage "44" @default.
• W1966338375 startingPage "39" @default.
• W1966338375 abstract "Estradiol quantitation is useful in the clinical assessment of diseases like hypogonadism, hirsutism, polycystic ovary syndrome (PCOS), amenorrhea, ovarian tumors and for monitoring response in women receiving aromatase inhibitor therapy. Physiologically relevant serum estradiol concentration in women can span across four orders of magnitude. For example, in women undergoing ovulation induction serum estradiol concentration can range between 250-2000 pg/mL whereas aromatase inhibitor therapy can decrease serum estradiol concentration to <5 pg/mL. While high-through-put automated un-extracted (direct) immunoassays accommodate the growing clinical need for estradiol quantitation, are amenable to implementation by most hospital clinical laboratories, they display a significant loss of specificity and accuracy at low concentrations. Most clinical scenarios (example: estradiol monitoring in fertility treatments) place a modest demand on accuracy and precision of the assay in use but accurate quantitation of estradiol in certain clinical scenarios (pediatric and male patients and for monitoring aromatase inhibitor therapy) can be challenging using currently available immunoassays since the direct immunoassays are prone to issues with sub-optimal accuracy and specificity due to cross reactivity with estradiol conjugates and metabolites. In this review we discuss the bases for the evolution of estradiol assays from extracted (indirect) radio-immunoassays to direct immunoassays to liquid-chromatography tandem mass spectrometry (LC-MS/MS) based assays, discuss technical factors relevant for development and optimization of a LC-MS/MS assay for estradiol and present the details and performance characteristics of an ultra-sensitive LC-MS/MS estradiol assay with a limit of quantitation of 0.2 pg/mL." @default.
• W1966338375 created "2016-06-24" @default.
• W1966338375 creator A5014885054 @default.
• W1966338375 creator A5055013326 @default.
• W1966338375 creator A5063258499 @default.
• W1966338375 date "2015-07-01" @default.
• W1966338375 modified "2023-10-13" @default.
• W1966338375 title "Estradiol assays – The path ahead" @default.
• W1966338375 cites W1514783140 @default.
• W1966338375 cites W1967607481 @default.
• W1966338375 cites W1979713715 @default.
• W1966338375 cites W1987499470 @default.
• W1966338375 cites W1987985529 @default.
• W1966338375 cites W1991714673 @default.
• W1966338375 cites W1992405425 @default.
• W1966338375 cites W1998401636 @default.
• W1966338375 cites W2008453715 @default.
• W1966338375 cites W2011485900 @default.
• W1966338375 cites W2037876998 @default.
• W1966338375 cites W2047038635 @default.
• W1966338375 cites W2047739157 @default.
• W1966338375 cites W2050847082 @default.
• W1966338375 cites W2059415318 @default.
• W1966338375 cites W2060011275 @default.
• W1966338375 cites W2091645978 @default.
• W1966338375 cites W2097563817 @default.
• W1966338375 cites W2101881391 @default.
• W1966338375 cites W2102203236 @default.
• W1966338375 cites W2106947567 @default.
• W1966338375 cites W2109430551 @default.
• W1966338375 cites W2110808214 @default.
• W1966338375 cites W2114481006 @default.
• W1966338375 cites W2122095366 @default.
• W1966338375 cites W2123130972 @default.
• W1966338375 cites W2123175299 @default.
• W1966338375 cites W2151921197 @default.
• W1966338375 cites W2321282239 @default.
• W1966338375 cites W3023173633 @default.
• W1966338375 cites W4253693469 @default.
• W1966338375 doi "https://doi.org/10.1016/j.steroids.2014.08.009" @default.
• W1966338375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25159104" @default.
• W1966338375 hasPublicationYear "2015" @default.
• W1966338375 type Work @default.
• W1966338375 sameAs 1966338375 @default.
• W1966338375 citedByCount "34" @default.
• W1966338375 countsByYear W19663383752016 @default.
• W1966338375 countsByYear W19663383752017 @default.
• W1966338375 countsByYear W19663383752018 @default.
• W1966338375 countsByYear W19663383752019 @default.
• W1966338375 countsByYear W19663383752020 @default.
• W1966338375 countsByYear W19663383752022 @default.
• W1966338375 countsByYear W19663383752023 @default.
• W1966338375 crossrefType "journal-article" @default.
• W1966338375 hasAuthorship W1966338375A5014885054 @default.
• W1966338375 hasAuthorship W1966338375A5055013326 @default.
• W1966338375 hasAuthorship W1966338375A5063258499 @default.
• W1966338375 hasConcept C121608353 @default.
• W1966338375 hasConcept C126322002 @default.
• W1966338375 hasConcept C134018914 @default.
• W1966338375 hasConcept C159654299 @default.
• W1966338375 hasConcept C185592680 @default.
• W1966338375 hasConcept C203014093 @default.
• W1966338375 hasConcept C2776166826 @default.
• W1966338375 hasConcept C2777164284 @default.
• W1966338375 hasConcept C2777391703 @default.
• W1966338375 hasConcept C2778504769 @default.
• W1966338375 hasConcept C2780420688 @default.
• W1966338375 hasConcept C2781197716 @default.
• W1966338375 hasConcept C3018442814 @default.
• W1966338375 hasConcept C43617362 @default.
• W1966338375 hasConcept C530470458 @default.
• W1966338375 hasConcept C55493867 @default.
• W1966338375 hasConcept C555293320 @default.
• W1966338375 hasConcept C71924100 @default.
• W1966338375 hasConceptScore W1966338375C121608353 @default.
• W1966338375 hasConceptScore W1966338375C126322002 @default.
• W1966338375 hasConceptScore W1966338375C134018914 @default.
• W1966338375 hasConceptScore W1966338375C159654299 @default.
• W1966338375 hasConceptScore W1966338375C185592680 @default.
• W1966338375 hasConceptScore W1966338375C203014093 @default.
• W1966338375 hasConceptScore W1966338375C2776166826 @default.
• W1966338375 hasConceptScore W1966338375C2777164284 @default.
• W1966338375 hasConceptScore W1966338375C2777391703 @default.
• W1966338375 hasConceptScore W1966338375C2778504769 @default.
• W1966338375 hasConceptScore W1966338375C2780420688 @default.
• W1966338375 hasConceptScore W1966338375C2781197716 @default.
• W1966338375 hasConceptScore W1966338375C3018442814 @default.
• W1966338375 hasConceptScore W1966338375C43617362 @default.
• W1966338375 hasConceptScore W1966338375C530470458 @default.
• W1966338375 hasConceptScore W1966338375C55493867 @default.
• W1966338375 hasConceptScore W1966338375C555293320 @default.
• W1966338375 hasConceptScore W1966338375C71924100 @default.
• W1966338375 hasLocation W19663383751 @default.
• W1966338375 hasLocation W19663383752 @default.
• W1966338375 hasOpenAccess W1966338375 @default.
• W1966338375 hasPrimaryLocation W19663383751 @default.
• W1966338375 hasRelatedWork W1968946548 @default.
• W1966338375 hasRelatedWork W1972333242 @default.

• next