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• W1966345655 abstract "<b>Background:</b> Much interest has been shown recently in the pathogenic role of B cells in rheumatoid arthritis (RA) owing to the marked clinical responses to anti-CD20 treatment in RA. <b>Case report:</b> A patient with X linked agammaglobulinaemia (XLA) presented with an erosive symmetric polyarthritis with histological features of RA, including formation of a destructive pannus. Furthermore, the patient developed subcutaneous nodules that were histologically indistinguishable from rheumatoid nodules. Surprisingly, lymphocytic infiltrates in both the synovium and nodule consisted almost exclusively of CD8⁺ T cells. <b>Discussion:</b> Although some peculiar B cell subsets have been described in patients with XLA, no B cell subsets could be demonstrated in synovial tissue or the subcutaneous nodule. This case illustrates that classical RA can develop in the absence of mature B cells." @default.
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• W1966345655 date "2005-07-01" @default.
• W1966345655 modified "2023-09-25" @default.
• W1966345655 title "X linked agammaglobulinaemia and rheumatoid arthritis" @default.
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• W1966345655 doi "https://doi.org/10.1136/ard.2004.030049" @default.
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