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- W1966346111 abstract "Isoprecipitins to a myeloma γA (Adj. PC-6A) immunoglobulin, of BALB/c mice prepared in A/He, AL and NH inbred strains of mice identified allotypic specificities (determinants) on the heavy polypeptide chains of the γA myeloma immunoglobulin, specifically the Fc fragment. The anti-myeloma γA antisera are specific for the myeloma γA class of immunoglobulins and distinguish among normal yA immunoglobulins in inbred strains of mice. Four allotypic specificities (determinants), A(12), A(13), A(14) and A(−), were found among 38 inbred strains. Isoantisera specific separately for determinants (13) on the γA and (7) on the γG heavy chains of BALB/c mice were used in genetic tests to test the sera of 758 backcross progeny of a cross of (C57BL/6 × BALB/c)F1 and C57BL/6 mice for precipitation. Sera of 366 of the same progeny showed neither the A(13) nor the G(7) determinants, whereas sera of 392 of the same progeny showed both the A(13) and G(7) determinants, indicating very close linkage in their genetic control. Thus far no recombinants have been found. Tryptic peptide maps of the γA and γG heavy chains and their Fc fragments differ by many peptides, indicating control by different structural genes." @default.
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- W1966346111 date "1966-07-01" @default.
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- W1966346111 title "Close linkage in genes controlling γA and γG heavy chain structure in BALB/c mice" @default.
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- W1966346111 doi "https://doi.org/10.1016/s0022-2836(66)80040-2" @default.
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