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- W1966346232 endingPage "054117" @default.
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- W1966346232 abstract "Metastatic cancer cells must traverse a microenvironment ranging from extremely hypoxic, within the tumor, to highly oxygenated, within the host's vasculature. Tumor hypoxia can be further characterized by regions of both chronic and intermittent hypoxia. We present the design and characterization of a microfluidic device that can simultaneously mimic the oxygenation conditions observed within the tumor and model the cell migration and intravasation processes. This device can generate spatial oxygen gradients of chronic hypoxia and produce dynamically changing hypoxic microenvironments in long-term culture of cancer cells." @default.
- W1966346232 created "2016-06-24" @default.
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- W1966346232 date "2014-09-01" @default.
- W1966346232 modified "2023-09-26" @default.
- W1966346232 title "A microfluidic device to study cancer metastasis under chronic and intermittent hypoxia" @default.
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- W1966346232 doi "https://doi.org/10.1063/1.4898788" @default.
- W1966346232 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4290574" @default.
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