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• W1966351844 endingPage "387" @default.
• W1966351844 startingPage "380" @default.
• W1966351844 abstract "Quantitative MR metrics (e.g., T1, T2, diffusion coefficients, and magnetization transfer ratios (MTRs etc)) are often derived from two images collected with one acquisition parameter changed between them (the two-point method). Since a low signal-to-noise-ratio (SNR) adversely affects the precision of these metrics, averaging is frequently used, although improvement accrues slowly-in proportion to the square root of imaging time. Fortunately, the relationship between the images' SNRs and the metric's precision can be exploited to our advantage. Using error propagation rules, we show that for a given sequence, specifying the total imaging time uniquely determines the optimal acquisition protocol. Specifically, instead of changing only one acquisition parameter and repeating the imaging pair until all available time is spent, we propose to adjust all of the parameters and the number of averages at each point according to their contribution to the sought metric's precision. The tactic is shown to increase the precision of the well-known two-point T1, T2, and diffusion coefficients estimation by 13-90% for the same sample, sequence, hardware, and duration. It is also shown that under this general framework, precision accrues faster than the square root of time. Tables of optimal parameters are provided for various experimental scenarios." @default.
• W1966351844 created "2016-06-24" @default.
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• W1966351844 date "2007-01-26" @default.
• W1966351844 modified "2023-10-16" @default.
• W1966351844 title "Optimizing the precision‐per‐unit‐time of quantitative MR metrics: Examples for <i>T</i>₁, <i>T</i>₂, and DTI" @default.
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• W1966351844 doi "https://doi.org/10.1002/mrm.21144" @default.
• W1966351844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17260375" @default.
• W1966351844 hasPublicationYear "2007" @default.
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