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- W1966353073 abstract "In order to investigate crystallographically the mechanism of inhibition of cysteine protease by α-methyl-γ,γ-diphenylallenecarboxylic acid ethyl ester 3, a cysteine protease inhibitor having in vivo stability, we synthesized N-(α-methyl-γ,γ-diphenylallenecarbonyl)-l-phenylalanine ethyl ester 4. Reaction of 4 with thiophenol, the SH group of which has similar pKa value to that of cysteine protease, produced oxygen-mediated radical adducts 6 and 7 in ambient air but did not proceed under oxygen-free conditions. Catalytic activities of two thiol enzymes including cathepsin B were also lowered in the absence of oxygen. These results suggest that cysteine protease can act through an oxygen-dependent radical mechanism." @default.
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- W1966353073 date "2008-12-01" @default.
- W1966353073 modified "2023-10-16" @default.
- W1966353073 title "Possible involvement of radical intermediates in the inhibition of cysteine proteases by allenyl esters and amides" @default.
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- W1966353073 doi "https://doi.org/10.1016/j.bmcl.2008.10.007" @default.
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