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• W1966355539 endingPage "621" @default.
• W1966355539 startingPage "609" @default.
• W1966355539 abstract "The complex nuclear structure of somatic cells is important to epigenomic regulation, yet little is known about nuclear organization of human embryonic stem cells (hESC). Here we surveyed several nuclear structures in pluripotent and transitioning hESC. Observations of centromeres, telomeres, SC35 speckles, Cajal Bodies, lamin A/C and emerin, nuclear shape and size demonstrate a very different nuclear landscape in hESC. This landscape is remodeled during a brief transitional window, concomitant with or just prior to differentiation onset. Notably, hESC initially contain abundant signal for spliceosome assembly factor, SC35, but lack discrete SC35 domains; these form as cells begin to specialize, likely reflecting cell-type specific genomic organization. Concomitantly, nuclear size increases and shape changes as lamin A/C and emerin incorporate into the lamina. During this brief window, hESC exhibit dramatically different PML-defined structures, which in somatic cells are linked to gene regulation and cancer. Unlike the numerous, spherical somatic PML bodies, hES cells often display approximately 1-3 large PML structures of two morphological types: long linear rods or elaborate rosettes, which lack substantial SUMO-1, Daxx, and Sp100. These occur primarily between Day 0-2 of differentiation and become rare thereafter. PML rods may be taut between other structures, such as centromeres, but clearly show some relationship with the lamina, where PML often abuts or fills a gap in early lamin A/C staining. Findings demonstrate that pluripotent hES cells have a markedly different overall nuclear architecture, remodeling of which is linked to early epigenomic programming and involves formation of unique PML-defined structures." @default.
• W1966355539 created "2016-06-24" @default.
• W1966355539 creator A5006711527 @default.
• W1966355539 creator A5070745892 @default.
• W1966355539 creator A5073437392 @default.
• W1966355539 creator A5080170366 @default.
• W1966355539 date "2009-07-01" @default.
• W1966355539 modified "2023-10-12" @default.
• W1966355539 title "Changing nuclear landscape and unique PML structures during early epigenetic transitions of human embryonic stem cells" @default.
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• W1966355539 doi "https://doi.org/10.1002/jcb.22183" @default.
• W1966355539 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2937361" @default.
• W1966355539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19449340" @default.
• W1966355539 hasPublicationYear "2009" @default.
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