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• W1966361118 startingPage "7305" @default.
• W1966361118 abstract "The dynamics of the furanose rings in the GCGC moiety of the DNA oligomer [d(G 1A 2T 3A 4 G 5 C 6 G 7 C 8T 9A 10T 11C 12)] 2 are studied by using deuterium solid-state NMR (SSNMR). SSNMR spectra obtained from DNAs selectively deuterated on the furanose rings of nucleotides within the 5'-GCGC-3' moiety indicated that all of these positions are structurally flexible. The furanose ring within the deoxycytidine that is the methylation target displays the largest-amplitude structural changes according to the observed deuterium NMR line shapes, whereas the furanose rings of nucleotides more remote from the methylation site have less-mobile furanose rings (i.e., with puckering amplitudes < 0.3 A). Previous work has shown that methylation reduces the amplitude of motion in the phosphodiester backbone of the same DNA, and our observations indicate that methylation perturbs backbone dynamics through the furanose ring. These NMR data indicate that the 5'-GCGC-3' is dynamic, with the largest-amplitude motions occurring nearest the methylation site. The inherent flexibility of this moiety in DNA makes the molecule more amenable to the large-amplitude structural rearrangements that must occur when the DNA binds to the HhaI methyltransferase." @default.
• W1966361118 created "2016-06-24" @default.
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• W1966361118 date "2008-05-20" @default.
• W1966361118 modified "2023-10-18" @default.
• W1966361118 title "Solid-State Nuclear Magnetic Resonance Spectroscopy Studies of Furanose Ring Dynamics in the DNA <i>Hha</i>I Binding Site" @default.
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• W1966361118 doi "https://doi.org/10.1021/ja075775n" @default.
• W1966361118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18489097" @default.
• W1966361118 hasPublicationYear "2008" @default.
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