Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966365853> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W1966365853 endingPage "236" @default.
- W1966365853 startingPage "231" @default.
- W1966365853 abstract "In an attempt to know the relation of seizure and gastric mucosal damage, we challenged arecoline (ACL) centrally to induce seizure and investigated gastric hemorrhagic injury in acid-irrigated stomachs of rats. The protective effects of several drugs also were evaluated. After deprivation of food for 24 h, rats were received laparotomy under diethylether-anesthesia. Both pylorus sphincters and carotid esophagus were ligated. The forestomach was equipped with a cannula for gastric irrigation. After recovery from anesthesia (approximately 1 h), the stomach was irrigated for 2 h with an acid solution containing 100 mM HCl and 54 mM NaCl or the same volume of normal saline. Intracerebroventricular (i.c.v.) ACL (0, 1, 3 or 10 mgkg dissolved in 10 μl of CSF) was challenged to rats immediately after gastric irrigation. The seizure in rats was produced by ACL in a dose-related manner. The ulcerogenic parameters such as decrease of gastric mucosal glutathione levels and increase of histamine concentrations and lipid peroxide generations as well as the raise of luminal hemoglobin contents and exacerbated mucosal lesions were obtained depending on the doses of ACL challenged. These ulcerogenic parameters produced in ACL (10 mgkg, i.c.v.) seizure rats were markedly ameliorated by gastric vagotomy or central anticholinergics. Intraperitoneal ketotifen, zinc sulfate, diphenhydramine or cimetidine also produced significant (p < 0.05) inhibitions of these ulcerogenic parameters in ACL seizure rats. In conclusion, central ACL seizure may produce gastric oxidative stress and hemorrhagic lesions via vagal nervous activation and histamine release in acid-irrigated stomachs of rats." @default.
- W1966365853 created "2016-06-24" @default.
- W1966365853 creator A5021089493 @default.
- W1966365853 creator A5032846897 @default.
- W1966365853 creator A5060748926 @default.
- W1966365853 creator A5073697596 @default.
- W1966365853 date "1983-05-01" @default.
- W1966365853 modified "2023-09-27" @default.
- W1966365853 title "A rapid and convenient freehand method for the implantation of cerebroventricular cannulae in rats" @default.
- W1966365853 cites W1498891976 @default.
- W1966365853 cites W1972586199 @default.
- W1966365853 cites W1981945027 @default.
- W1966365853 cites W2041443783 @default.
- W1966365853 cites W2077123327 @default.
- W1966365853 cites W2087203878 @default.
- W1966365853 cites W2200037724 @default.
- W1966365853 doi "https://doi.org/10.1016/0160-5402(83)90042-6" @default.
- W1966365853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6876813" @default.
- W1966365853 hasPublicationYear "1983" @default.
- W1966365853 type Work @default.
- W1966365853 sameAs 1966365853 @default.
- W1966365853 citedByCount "13" @default.
- W1966365853 crossrefType "journal-article" @default.
- W1966365853 hasAuthorship W1966365853A5021089493 @default.
- W1966365853 hasAuthorship W1966365853A5032846897 @default.
- W1966365853 hasAuthorship W1966365853A5060748926 @default.
- W1966365853 hasAuthorship W1966365853A5073697596 @default.
- W1966365853 hasConcept C1122143 @default.
- W1966365853 hasConcept C126322002 @default.
- W1966365853 hasConcept C134018914 @default.
- W1966365853 hasConcept C141071460 @default.
- W1966365853 hasConcept C2777397205 @default.
- W1966365853 hasConcept C2778012502 @default.
- W1966365853 hasConcept C2778074680 @default.
- W1966365853 hasConcept C2778720886 @default.
- W1966365853 hasConcept C2779422922 @default.
- W1966365853 hasConcept C2780719153 @default.
- W1966365853 hasConcept C2781263782 @default.
- W1966365853 hasConcept C42219234 @default.
- W1966365853 hasConcept C71924100 @default.
- W1966365853 hasConceptScore W1966365853C1122143 @default.
- W1966365853 hasConceptScore W1966365853C126322002 @default.
- W1966365853 hasConceptScore W1966365853C134018914 @default.
- W1966365853 hasConceptScore W1966365853C141071460 @default.
- W1966365853 hasConceptScore W1966365853C2777397205 @default.
- W1966365853 hasConceptScore W1966365853C2778012502 @default.
- W1966365853 hasConceptScore W1966365853C2778074680 @default.
- W1966365853 hasConceptScore W1966365853C2778720886 @default.
- W1966365853 hasConceptScore W1966365853C2779422922 @default.
- W1966365853 hasConceptScore W1966365853C2780719153 @default.
- W1966365853 hasConceptScore W1966365853C2781263782 @default.
- W1966365853 hasConceptScore W1966365853C42219234 @default.
- W1966365853 hasConceptScore W1966365853C71924100 @default.
- W1966365853 hasIssue "3" @default.
- W1966365853 hasLocation W19663658531 @default.
- W1966365853 hasLocation W19663658532 @default.
- W1966365853 hasOpenAccess W1966365853 @default.
- W1966365853 hasPrimaryLocation W19663658531 @default.
- W1966365853 hasRelatedWork W1965692775 @default.
- W1966365853 hasRelatedWork W1983315707 @default.
- W1966365853 hasRelatedWork W1992532976 @default.
- W1966365853 hasRelatedWork W2036355984 @default.
- W1966365853 hasRelatedWork W2137838591 @default.
- W1966365853 hasRelatedWork W2412730628 @default.
- W1966365853 hasRelatedWork W4237601915 @default.
- W1966365853 hasRelatedWork W4255419199 @default.
- W1966365853 hasRelatedWork W4293578753 @default.
- W1966365853 hasRelatedWork W1965947048 @default.
- W1966365853 hasVolume "9" @default.
- W1966365853 isParatext "false" @default.
- W1966365853 isRetracted "false" @default.
- W1966365853 magId "1966365853" @default.
- W1966365853 workType "article" @default.