FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W196636632> ?p ?o ?g. }

• W196636632 endingPage "763" @default.
• W196636632 startingPage "751" @default.
• W196636632 abstract "In early phases of neuromuscular disease, patients are either free of respiratory symptoms or have exertional dyspnea not explained by obvious obstructive or restrictive lung disease. Physical examination may be negative because generalized muscle weakness does not correlate with the degree of respiratory muscle involvement. When the diaphragm is involved, one may detect the absence of outward excursion during inspiration or even paradoxic inward inspiratory movement of the abdomen on one side. A substantial loss of respiratory muscle strength is typically accompanied by little or no change in spirometry or arterial blood gas composition. Other characteristics are moderate loss of maximal voluntary ventilation and an increase in residual volume, yet Pimax and Pemax may be as low as 50% of the predicted value. In more advanced neuromuscular disease, patients may have severe symptoms if the onset is acute or subacute; however, patients with chronic advanced generalized muscle weakness do not exercise and, therefore, may not be breathless. Many patients with advanced neuromuscular disease present with daytime somnolence as a manifestation of a sleep-related breathing disorder. Physical examination may reveal generalized muscle weakness and difficulty with speech or swallowing. Signs specific to respiratory involvement include tachypnea, use of neck inspiratory muscles and abdominal expiratory muscles, and loss of chest-abdomen synchrony. Sometimes paradoxic bilateral inward movement of the abdomen with inspiration is overt. Patients may be unable to cough effectively, have scoliosis, and lack a gag reflex. At this advanced stage, Pimax and Pemax are lower than 50% of the predicted value, and the vital capacity is reduced. Maximal voluntary ventilation increases, and residual volume increases further. Patients may not yet exhibit CO2 retention during the day and may even have a low Paco2.13 A sleep study may reveal significant hypopneas with severe desaturation and hypercapnia, especially during REM sleep. It is important to be aware that overt ventilatory failure can occur abruptly and that measurement of arterial blood gas composition is not a reliable indicator of this danger. Therefore, it is critically important to heed clinical phenomena, such as increasing dyspnea and tachypnea, and symptoms of sleep disturbance, such as morning headache and daytime somnolence. Physicians should make serial measurements of VC and respiratory muscle strength in patients considered to be at risk for further deterioration. The Paco2 reaches ventilatory failure levels when the VC falls below one half the normal value.13 The Paco2 exceeds the normal range when respiratory muscle strength is 30% or less of normal values, but lesser degrees of respiratory muscle weakness can precipitate ventilatory failure when lung disease is coexistent.13" @default.
• W196636632 created "2016-06-24" @default.
• W196636632 creator A5054382709 @default.
• W196636632 creator A5057529107 @default.
• W196636632 date "1994-12-01" @default.
• W196636632 modified "2023-10-01" @default.
• W196636632 title "ASSESSMENT OF VENTILATORY FUNCTION IN PATIENTS WITH NEUROMUSCULAR DISEASE" @default.
• W196636632 cites W148388261 @default.
• W196636632 cites W1526177195 @default.
• W196636632 cites W1562541234 @default.
• W196636632 cites W1650578309 @default.
• W196636632 cites W1844932135 @default.
• W196636632 cites W1894477602 @default.
• W196636632 cites W190997383 @default.
• W196636632 cites W1951303749 @default.
• W196636632 cites W1963763972 @default.
• W196636632 cites W1964941358 @default.
• W196636632 cites W1965870046 @default.
• W196636632 cites W1970563481 @default.
• W196636632 cites W1978665704 @default.
• W196636632 cites W1980359426 @default.
• W196636632 cites W1985849753 @default.
• W196636632 cites W1989177945 @default.
• W196636632 cites W1992522069 @default.
• W196636632 cites W1994973511 @default.
• W196636632 cites W2001719398 @default.
• W196636632 cites W2002913521 @default.
• W196636632 cites W2003166195 @default.
• W196636632 cites W2003630245 @default.
• W196636632 cites W2004889123 @default.
• W196636632 cites W2005780407 @default.
• W196636632 cites W2008985605 @default.
• W196636632 cites W2016624905 @default.
• W196636632 cites W2016977589 @default.
• W196636632 cites W2019317697 @default.
• W196636632 cites W2022149468 @default.
• W196636632 cites W2022383059 @default.
• W196636632 cites W2022721499 @default.
• W196636632 cites W2036580555 @default.
• W196636632 cites W2036751199 @default.
• W196636632 cites W2037097901 @default.
• W196636632 cites W2040606931 @default.
• W196636632 cites W2045383272 @default.
• W196636632 cites W2055039774 @default.
• W196636632 cites W2055187364 @default.
• W196636632 cites W2059587123 @default.
• W196636632 cites W2061380815 @default.
• W196636632 cites W2065701001 @default.
• W196636632 cites W2066518885 @default.
• W196636632 cites W2067882753 @default.
• W196636632 cites W2070084929 @default.
• W196636632 cites W2070152655 @default.
• W196636632 cites W2070198866 @default.
• W196636632 cites W2074578356 @default.
• W196636632 cites W2075011215 @default.
• W196636632 cites W2081937727 @default.
• W196636632 cites W2082351240 @default.
• W196636632 cites W2084628187 @default.
• W196636632 cites W2085409099 @default.
• W196636632 cites W2085557436 @default.
• W196636632 cites W2087369311 @default.
• W196636632 cites W2099772251 @default.
• W196636632 cites W2102538943 @default.
• W196636632 cites W2114184820 @default.
• W196636632 cites W2122904798 @default.
• W196636632 cites W2128637198 @default.
• W196636632 cites W2130016116 @default.
• W196636632 cites W2130577637 @default.
• W196636632 cites W2133605423 @default.
• W196636632 cites W2136522688 @default.
• W196636632 cites W2146920721 @default.
• W196636632 cites W2155235303 @default.
• W196636632 cites W2157608306 @default.
• W196636632 cites W2158212594 @default.
• W196636632 cites W2158376012 @default.
• W196636632 cites W2169376032 @default.
• W196636632 cites W218200070 @default.
• W196636632 cites W2184519318 @default.
• W196636632 cites W2337280970 @default.
• W196636632 cites W2405657411 @default.
• W196636632 cites W38353050 @default.
• W196636632 doi "https://doi.org/10.1016/s0272-5231(21)00967-9" @default.
• W196636632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7867289" @default.
• W196636632 hasPublicationYear "1994" @default.
• W196636632 type Work @default.
• W196636632 sameAs 196636632 @default.
• W196636632 citedByCount "69" @default.
• W196636632 countsByYear W1966366322012 @default.
• W196636632 countsByYear W1966366322013 @default.
• W196636632 countsByYear W1966366322014 @default.
• W196636632 countsByYear W1966366322015 @default.
• W196636632 countsByYear W1966366322016 @default.
• W196636632 countsByYear W1966366322017 @default.
• W196636632 countsByYear W1966366322018 @default.
• W196636632 countsByYear W1966366322019 @default.
• W196636632 countsByYear W1966366322020 @default.
• W196636632 countsByYear W1966366322022 @default.
• W196636632 crossrefType "journal-article" @default.

• next