Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966370003> ?p ?o ?g. }
- W1966370003 endingPage "10" @default.
- W1966370003 startingPage "1" @default.
- W1966370003 abstract "1. The ischaemic penumbra is defined as a moderately hypoperfused region that retains structural integrity but has lost function. In animal models of ischaemic stroke, this region is prone to recurrent anoxic depolarization and will become infarcted if reperfusion does not occur. In the macaque model, an ischaemic penumbra has been identified for up to 3 h after ischaemic stroke onset, whereas in selected human patients it may exist for up to 48 h. 2. Although most definitions of the ischaemic penumbra stress a ‘time–brain volume’ concept, few incorporate the idea that selective and delayed neuronal injury plays an important role. Thus, in addition to necrotic cell death caused by acute injury, it is important to also consider delayed death mediated by caspase-dependent and -independent apoptotic pathways. 3. ‘Salvage’ of penumbral tissue is possible if reperfusion (e.g. after thrombolysis) occurs. However, neurons within this ‘salvaged’ region may be still at risk of further delayed neuronal injury. 4. In the present review, we aim to revisit the concept of the ischaemic penumbra and explore the role of selective and delayed neuronal injury in enlargement of the volume of infarction, as well as pathogenic mechanisms of white matter ischaemia. Both animal and human models of cerebral ischaemia imaged using magnetic resonance and positron emission tomography techniques will be discussed." @default.
- W1966370003 created "2016-06-24" @default.
- W1966370003 creator A5023696637 @default.
- W1966370003 creator A5027934522 @default.
- W1966370003 creator A5033576303 @default.
- W1966370003 creator A5035071406 @default.
- W1966370003 creator A5039358787 @default.
- W1966370003 creator A5056972691 @default.
- W1966370003 date "2002-01-14" @default.
- W1966370003 modified "2023-09-25" @default.
- W1966370003 title "Salvaging The Ischaemic Penumbra: More Than Just Reperfusion?" @default.
- W1966370003 cites W1566676785 @default.
- W1966370003 cites W1566984812 @default.
- W1966370003 cites W1655344346 @default.
- W1966370003 cites W1812279404 @default.
- W1966370003 cites W1820347542 @default.
- W1966370003 cites W1913635668 @default.
- W1966370003 cites W1928529925 @default.
- W1966370003 cites W1941497446 @default.
- W1966370003 cites W1964100686 @default.
- W1966370003 cites W1965119464 @default.
- W1966370003 cites W1965217295 @default.
- W1966370003 cites W1974483939 @default.
- W1966370003 cites W1974719637 @default.
- W1966370003 cites W1976140941 @default.
- W1966370003 cites W1976467696 @default.
- W1966370003 cites W1980369396 @default.
- W1966370003 cites W1984098569 @default.
- W1966370003 cites W1985339713 @default.
- W1966370003 cites W1988171628 @default.
- W1966370003 cites W1988340492 @default.
- W1966370003 cites W2009926580 @default.
- W1966370003 cites W2017201352 @default.
- W1966370003 cites W2029479814 @default.
- W1966370003 cites W2029744927 @default.
- W1966370003 cites W2035023461 @default.
- W1966370003 cites W2040958707 @default.
- W1966370003 cites W2046938559 @default.
- W1966370003 cites W2049886823 @default.
- W1966370003 cites W2053200671 @default.
- W1966370003 cites W2059914905 @default.
- W1966370003 cites W2061497413 @default.
- W1966370003 cites W2062793260 @default.
- W1966370003 cites W2067436359 @default.
- W1966370003 cites W2070749449 @default.
- W1966370003 cites W2072639955 @default.
- W1966370003 cites W2072926617 @default.
- W1966370003 cites W2077484357 @default.
- W1966370003 cites W2077983790 @default.
- W1966370003 cites W2078801546 @default.
- W1966370003 cites W2083893789 @default.
- W1966370003 cites W2085178582 @default.
- W1966370003 cites W2086434994 @default.
- W1966370003 cites W2089276235 @default.
- W1966370003 cites W2094707199 @default.
- W1966370003 cites W2096174742 @default.
- W1966370003 cites W2099292921 @default.
- W1966370003 cites W2099706007 @default.
- W1966370003 cites W2109918847 @default.
- W1966370003 cites W2110035983 @default.
- W1966370003 cites W2112646710 @default.
- W1966370003 cites W2113999599 @default.
- W1966370003 cites W2118981271 @default.
- W1966370003 cites W2120683729 @default.
- W1966370003 cites W2123894485 @default.
- W1966370003 cites W2127242185 @default.
- W1966370003 cites W2136072416 @default.
- W1966370003 cites W2136781825 @default.
- W1966370003 cites W2140327468 @default.
- W1966370003 cites W2141347187 @default.
- W1966370003 cites W2151982496 @default.
- W1966370003 cites W2157645771 @default.
- W1966370003 cites W2158188707 @default.
- W1966370003 cites W2164554425 @default.
- W1966370003 cites W2292308933 @default.
- W1966370003 cites W2317448591 @default.
- W1966370003 cites W2977568416 @default.
- W1966370003 cites W4214929850 @default.
- W1966370003 cites W8515037 @default.
- W1966370003 doi "https://doi.org/10.1046/j.1440-1681.2002.03609.x" @default.
- W1966370003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11917903" @default.
- W1966370003 hasPublicationYear "2002" @default.
- W1966370003 type Work @default.
- W1966370003 sameAs 1966370003 @default.
- W1966370003 citedByCount "83" @default.
- W1966370003 countsByYear W19663700032012 @default.
- W1966370003 countsByYear W19663700032013 @default.
- W1966370003 countsByYear W19663700032014 @default.
- W1966370003 countsByYear W19663700032015 @default.
- W1966370003 countsByYear W19663700032016 @default.
- W1966370003 countsByYear W19663700032017 @default.
- W1966370003 countsByYear W19663700032018 @default.
- W1966370003 countsByYear W19663700032019 @default.
- W1966370003 countsByYear W19663700032020 @default.
- W1966370003 countsByYear W19663700032021 @default.
- W1966370003 countsByYear W19663700032023 @default.
- W1966370003 crossrefType "journal-article" @default.
- W1966370003 hasAuthorship W1966370003A5023696637 @default.