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• W1966373586 abstract "This work describes the behavioural responses of Sprague–Dawley rats to mechanical or thermal stimuli during and after administration of ten intraperitoneal injections of, alternatively, 1 and 2 mg/kg cisplatin every three days (cumulative dose: 15 mg/kg). Nociceptive signs including mechanical allodynia and hyperalgesia appeared after 3 and 6 cisplatin injections, respectively, and were maintained until 15 days after the last injection. The conservation of a good clinical status and fast appearance of symptoms are favourable criteria for using this animal model to understand the pathophysiological mechanisms implicated in the cisplatin-induced sensory peripheral neuropathy." @default.
• W1966373586 created "2016-06-24" @default.
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• W1966373586 date "2000-09-01" @default.
• W1966373586 modified "2023-10-01" @default.
• W1966373586 title "Assessment of allodynia and hyperalgesia after cisplatin administration to rats" @default.
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• W1966373586 doi "https://doi.org/10.1016/s0304-3940(00)01373-2" @default.
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