Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966373896> ?p ?o ?g. }
- W1966373896 endingPage "1110" @default.
- W1966373896 startingPage "1101" @default.
- W1966373896 abstract "It is believed that the mammalian epididymis participates in the maturation of the sperm due to its secretory activity. High concentrations of several secreted acid hydrolases are found in the epididymal lumen. Moreover, some of these enzymes are secreted by the epididymal epithelium in an androgen-dependent fashion. In this study, we attempted to discern whether mannose-6-phosphate receptors (MPRs) regulate transport and secretion of lysosomal enzymes in the rat epididymis, and if these events are altered when the animals are subjected to hormonal manipulation. We observed that expression of cation-dependent MPR (CD-MPR) and cation-independent MPR (CI-MPR) increased significantly in caudal epididymis of castrated rats by immunoblot. This increase was corroborated by quantitation of MPRs, by binding assays. This change could be due to androgen deprivation, as a similar effect was observed after treatment with the anti-androgenic drug flutamide. Furthermore, we observed that the CD-MPR was redistributed to the apical area of the epithelium on castrated rats by immunohistochemistry, which is compatible with the redistribution of the receptors toward lighter fractions in a Percoll gradient. Consistent with a possible involvement of the CD-MPR in the secretion, we observed an increase in pro-cathepsin D levels in epididymal fluid after castration. We conclude that the CD-MPR might be regulated by hormones and that this receptor might be involved in the secretion of specific enzymes into the rat epididymis." @default.
- W1966373896 created "2016-06-24" @default.
- W1966373896 creator A5010713777 @default.
- W1966373896 creator A5051420643 @default.
- W1966373896 creator A5056897062 @default.
- W1966373896 creator A5063255808 @default.
- W1966373896 creator A5063889622 @default.
- W1966373896 date "2010-04-28" @default.
- W1966373896 modified "2023-09-27" @default.
- W1966373896 title "Castration induces changes in the cation-dependent mannose-6-phosphate receptor in rat epididymis: Possible implications in secretion of lysosomal enzymes" @default.
- W1966373896 cites W1524086522 @default.
- W1966373896 cites W1544577728 @default.
- W1966373896 cites W1566862745 @default.
- W1966373896 cites W1775749144 @default.
- W1966373896 cites W187827060 @default.
- W1966373896 cites W1966279302 @default.
- W1966373896 cites W1972131742 @default.
- W1966373896 cites W1974932783 @default.
- W1966373896 cites W1983406329 @default.
- W1966373896 cites W1994900003 @default.
- W1966373896 cites W2001639671 @default.
- W1966373896 cites W2001816734 @default.
- W1966373896 cites W2004823702 @default.
- W1966373896 cites W2005564654 @default.
- W1966373896 cites W2006412125 @default.
- W1966373896 cites W2009845536 @default.
- W1966373896 cites W2014461574 @default.
- W1966373896 cites W2023271648 @default.
- W1966373896 cites W2027289933 @default.
- W1966373896 cites W2042195196 @default.
- W1966373896 cites W2066612720 @default.
- W1966373896 cites W2069226524 @default.
- W1966373896 cites W2076085125 @default.
- W1966373896 cites W2078846752 @default.
- W1966373896 cites W2085107209 @default.
- W1966373896 cites W2087126022 @default.
- W1966373896 cites W2095017414 @default.
- W1966373896 cites W2098766094 @default.
- W1966373896 cites W2100831483 @default.
- W1966373896 cites W2100837269 @default.
- W1966373896 cites W2104655459 @default.
- W1966373896 cites W2106640891 @default.
- W1966373896 cites W2115539249 @default.
- W1966373896 cites W2121474371 @default.
- W1966373896 cites W2138006763 @default.
- W1966373896 cites W2144110110 @default.
- W1966373896 cites W2144130844 @default.
- W1966373896 cites W2148143437 @default.
- W1966373896 cites W2151779932 @default.
- W1966373896 cites W2155757845 @default.
- W1966373896 cites W2155921154 @default.
- W1966373896 cites W2170801355 @default.
- W1966373896 cites W51663865 @default.
- W1966373896 doi "https://doi.org/10.1002/jcb.22622" @default.
- W1966373896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20564206" @default.
- W1966373896 hasPublicationYear "2010" @default.
- W1966373896 type Work @default.
- W1966373896 sameAs 1966373896 @default.
- W1966373896 citedByCount "9" @default.
- W1966373896 countsByYear W19663738962012 @default.
- W1966373896 countsByYear W19663738962013 @default.
- W1966373896 countsByYear W19663738962016 @default.
- W1966373896 countsByYear W19663738962018 @default.
- W1966373896 countsByYear W19663738962020 @default.
- W1966373896 countsByYear W19663738962021 @default.
- W1966373896 countsByYear W19663738962023 @default.
- W1966373896 crossrefType "journal-article" @default.
- W1966373896 hasAuthorship W1966373896A5010713777 @default.
- W1966373896 hasAuthorship W1966373896A5051420643 @default.
- W1966373896 hasAuthorship W1966373896A5056897062 @default.
- W1966373896 hasAuthorship W1966373896A5063255808 @default.
- W1966373896 hasAuthorship W1966373896A5063889622 @default.
- W1966373896 hasConcept C126322002 @default.
- W1966373896 hasConcept C134018914 @default.
- W1966373896 hasConcept C170493617 @default.
- W1966373896 hasConcept C185592680 @default.
- W1966373896 hasConcept C2781087480 @default.
- W1966373896 hasConcept C2781254305 @default.
- W1966373896 hasConcept C49039625 @default.
- W1966373896 hasConcept C529295009 @default.
- W1966373896 hasConcept C54355233 @default.
- W1966373896 hasConcept C55493867 @default.
- W1966373896 hasConcept C59822182 @default.
- W1966373896 hasConcept C71924100 @default.
- W1966373896 hasConcept C86803240 @default.
- W1966373896 hasConceptScore W1966373896C126322002 @default.
- W1966373896 hasConceptScore W1966373896C134018914 @default.
- W1966373896 hasConceptScore W1966373896C170493617 @default.
- W1966373896 hasConceptScore W1966373896C185592680 @default.
- W1966373896 hasConceptScore W1966373896C2781087480 @default.
- W1966373896 hasConceptScore W1966373896C2781254305 @default.
- W1966373896 hasConceptScore W1966373896C49039625 @default.
- W1966373896 hasConceptScore W1966373896C529295009 @default.
- W1966373896 hasConceptScore W1966373896C54355233 @default.
- W1966373896 hasConceptScore W1966373896C55493867 @default.
- W1966373896 hasConceptScore W1966373896C59822182 @default.
- W1966373896 hasConceptScore W1966373896C71924100 @default.
- W1966373896 hasConceptScore W1966373896C86803240 @default.