Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966375908> ?p ?o ?g. }
- W1966375908 endingPage "2718" @default.
- W1966375908 startingPage "2709" @default.
- W1966375908 abstract "Abstract Immunization with Schistosoma mansoni soluble antigen preparations protects non‐obese diabetic (NOD) mice against the development of type 1 diabetes. These preparations have long been known to induce Th2 responses in vitro and in vivo. Recently, two separate groups have reported that ω‐1, a well‐characterized glycoprotein in S. mansoni soluble egg antigens (SEA), which with IL‐4 inducing principle of S. mansoni eggs (IPSE/α‐1) is one of the two major glycoproteins secreted by live eggs, is a major SEA component responsible for this effect. We found that ω‐1 induces Foxp3 as well as IL‐4 expression when injected in vivo. We confirmed that ω‐1 conditions DCs to drive Th2 responses and further demonstrated that ω‐1 induces Foxp3 + T cells from NOD mouse naïve T cells. In contrast, IPSE/α‐1 did not drive Foxp3 responses. The in vitro development of Foxp3‐expressing T cells by ω‐1 was TGF‐β‐ and retinoic acid‐dependent. Our work, therefore, identifies ω‐1 as an important factor for the induction of Foxp3 + T cells by SEA in NOD mice." @default.
- W1966375908 created "2016-06-24" @default.
- W1966375908 creator A5003869260 @default.
- W1966375908 creator A5007093695 @default.
- W1966375908 creator A5016942680 @default.
- W1966375908 creator A5035854703 @default.
- W1966375908 creator A5048612586 @default.
- W1966375908 creator A5056361179 @default.
- W1966375908 creator A5058940752 @default.
- W1966375908 creator A5059940755 @default.
- W1966375908 creator A5066791310 @default.
- W1966375908 creator A5071413834 @default.
- W1966375908 date "2011-08-04" @default.
- W1966375908 modified "2023-10-18" @default.
- W1966375908 title "The S. mansoni glycoprotein ω-1 induces Foxp3 expression in NOD mouse CD4+ T cells" @default.
- W1966375908 cites W1575754639 @default.
- W1966375908 cites W1805059698 @default.
- W1966375908 cites W1972606545 @default.
- W1966375908 cites W1983741693 @default.
- W1966375908 cites W1983982592 @default.
- W1966375908 cites W1986109976 @default.
- W1966375908 cites W1990295653 @default.
- W1966375908 cites W1996176128 @default.
- W1966375908 cites W1997785544 @default.
- W1966375908 cites W2016451329 @default.
- W1966375908 cites W2022322779 @default.
- W1966375908 cites W2030480975 @default.
- W1966375908 cites W2031799130 @default.
- W1966375908 cites W2033260397 @default.
- W1966375908 cites W2037798159 @default.
- W1966375908 cites W2037949568 @default.
- W1966375908 cites W2042379875 @default.
- W1966375908 cites W2042854425 @default.
- W1966375908 cites W2053923770 @default.
- W1966375908 cites W2054302306 @default.
- W1966375908 cites W2072392320 @default.
- W1966375908 cites W2091483766 @default.
- W1966375908 cites W2104058586 @default.
- W1966375908 cites W2110957620 @default.
- W1966375908 cites W2114089512 @default.
- W1966375908 cites W2114611113 @default.
- W1966375908 cites W2115359896 @default.
- W1966375908 cites W2127379971 @default.
- W1966375908 cites W2129113472 @default.
- W1966375908 cites W2129195610 @default.
- W1966375908 cites W2133355123 @default.
- W1966375908 cites W2144836936 @default.
- W1966375908 cites W2146875241 @default.
- W1966375908 cites W2147858215 @default.
- W1966375908 cites W2152014005 @default.
- W1966375908 cites W2155022710 @default.
- W1966375908 cites W2155370249 @default.
- W1966375908 cites W2155510706 @default.
- W1966375908 cites W2157465673 @default.
- W1966375908 cites W2410372394 @default.
- W1966375908 doi "https://doi.org/10.1002/eji.201141429" @default.
- W1966375908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21710488" @default.
- W1966375908 hasPublicationYear "2011" @default.
- W1966375908 type Work @default.
- W1966375908 sameAs 1966375908 @default.
- W1966375908 citedByCount "82" @default.
- W1966375908 countsByYear W19663759082012 @default.
- W1966375908 countsByYear W19663759082013 @default.
- W1966375908 countsByYear W19663759082014 @default.
- W1966375908 countsByYear W19663759082015 @default.
- W1966375908 countsByYear W19663759082016 @default.
- W1966375908 countsByYear W19663759082017 @default.
- W1966375908 countsByYear W19663759082018 @default.
- W1966375908 countsByYear W19663759082019 @default.
- W1966375908 countsByYear W19663759082020 @default.
- W1966375908 countsByYear W19663759082021 @default.
- W1966375908 countsByYear W19663759082022 @default.
- W1966375908 countsByYear W19663759082023 @default.
- W1966375908 crossrefType "journal-article" @default.
- W1966375908 hasAuthorship W1966375908A5003869260 @default.
- W1966375908 hasAuthorship W1966375908A5007093695 @default.
- W1966375908 hasAuthorship W1966375908A5016942680 @default.
- W1966375908 hasAuthorship W1966375908A5035854703 @default.
- W1966375908 hasAuthorship W1966375908A5048612586 @default.
- W1966375908 hasAuthorship W1966375908A5056361179 @default.
- W1966375908 hasAuthorship W1966375908A5058940752 @default.
- W1966375908 hasAuthorship W1966375908A5059940755 @default.
- W1966375908 hasAuthorship W1966375908A5066791310 @default.
- W1966375908 hasAuthorship W1966375908A5071413834 @default.
- W1966375908 hasBestOaLocation W19663759081 @default.
- W1966375908 hasConcept C108625454 @default.
- W1966375908 hasConcept C147483822 @default.
- W1966375908 hasConcept C153911025 @default.
- W1966375908 hasConcept C165901193 @default.
- W1966375908 hasConcept C202751555 @default.
- W1966375908 hasConcept C203014093 @default.
- W1966375908 hasConcept C207001950 @default.
- W1966375908 hasConcept C2776225656 @default.
- W1966375908 hasConcept C2776863245 @default.
- W1966375908 hasConcept C2779727006 @default.
- W1966375908 hasConcept C54355233 @default.
- W1966375908 hasConcept C55493867 @default.
- W1966375908 hasConcept C55851684 @default.