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• W1966377524 abstract "BackgroundThe polymorphism COMTval158met has been associated with suicidal behavior in case-control and meta-analysis studies, but results and conclusions remain controversial. The objective of this study was to examine the association between COMT val158met with suicidal behavior in a case-control study and to assess the combined evidence -this case-control study and available data from other related studies- we carried out a meta-analysis.MethodsWe conducted a case-control study with 105 patients with suicide attempts and 236 controls. Subsequently, we performed a meta-analysis of published genetic association studies by searching through Medline, PubMed and Web of Science databases.ResultsNo significant differences were found in the distribution of alleles (χ2 = 0.33, 1 df, p = 0.56) or genotypes (χ2 = 2.36, 2 df, p = 0.26). The meta-analysis comprising 12 association studies (including the present one) showed that the risk COMTmet allele of COMTval158/met is not associated with suicidal behavior (OR: 1.09, 95% CI: 0.97-1.23), even in the absence of heterogeneity (OR: 1.09, 95% CI: 0.97-1.23).ConclusionOur results showed no association between COMTval158/met and suicidal behavior. However, more studies are necessary to determine conclusively an association between COMT and suicidal behavior." @default.
• W1966377524 created "2016-06-24" @default.
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• W1966377524 date "2011-09-21" @default.
• W1966377524 modified "2023-10-12" @default.
• W1966377524 title "No association between COMT val158met polymorphism and suicidal behavior: meta-analysis and new data" @default.
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• W1966377524 doi "https://doi.org/10.1186/1471-244x-11-151" @default.
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