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- W1966377689 abstract "A study of the embryotoxic and DNA synthesis inhibiting properties of hydroxyurea on 12-day rat embryos is presented. A profound depression of DNA synthesis was evident after all doses studied including a nonteratogenic dose. The time required to return to control synthetic levels was roughly proportional to dosage. The finding of effective hydroxyurea levels in the embryo strengthens the idea of a direct effect on embryonic cells as the cause of malformations and reveals that embryo cells respond to similar concentrations of hydroxyurea as do other cell types. Finally, the ability of hydroxyurea to produce early cell death in localized areas of the rat embryo is shown. Extensive cell death in the limbbud is followed at term by malformations in that structure. Surprisingly, however, extensive cell death in the neural tube does not lead to gross malformations of the central nervous system." @default.
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- W1966377689 date "1971-10-01" @default.
- W1966377689 modified "2023-10-18" @default.
- W1966377689 title "DNA synthesis inhibition and cell death associated with hydroxyurea teratogenesis in rat embryos" @default.
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- W1966377689 doi "https://doi.org/10.1016/0012-1606(71)90129-1" @default.
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