FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966388845> ?p ?o ?g. }

• W1966388845 endingPage "4495" @default.
• W1966388845 startingPage "4488" @default.
• W1966388845 abstract "ABSTRACT Combinations of KIR3DL1 and HLA-Bw4 alleles protect against HIV infection and/or disease progression. These combinations enhance NK cell responsiveness through the ontological process of education. However, educated KIR3DL1 + NK cells do not have enhanced degranulation upon direct recognition of autologous HIV-infected cells. Since antibody-dependent cellular cytotoxicity (ADCC) is associated with improved HIV infection outcomes and NK cells overcome inhibition through killer cell immunoglobulin-like receptors (KIR) to mediate ADCC, we hypothesized that KIR3DL1-educated NK cells mediate anti-HIV ADCC against autologous cells. A whole-blood flow cytometry assay was used to evaluate ADCC-induced activation of NK cells. This assay assessed activation (gamma interferon [IFN-γ] production and/or CD107a expression) of KIR3DL1 + and KIR3DL1 − NK cells, from HLA-Bw4 + and HLA-Bw4 − HIV-positive and HIV-negative individuals, in response to autologous HIV-specific ADCC targets. KIR3DL1 + NK cells were more functional than KIR3DL1 − NK cells from HLA-Bw4 + , but not HLA-Bw4 − , healthy controls. In HIV-infected individuals, no differences in NK cell functionality were observed between KIR3DL1 + and KIR3DL1 − NK cells in HLA-Bw4 + individuals, consistent with dysfunction of NK cells in the setting of HIV infection. Reflecting the partial normalization of NK cell responsiveness following initiation of antiretroviral therapy, a significant correlation was observed between the peripheral CD4 + T-lymphocyte counts in antiretroviral therapy-treated subjects and the functionality of NK cells. However, peripheral CD4 + T-lymphocyte counts were not correlated with an anti-HIV ADCC functional advantage in educated KIR3DL1 + NK cells. The abrogation of the functional advantage of educated NK cells may enhance HIV disease progression. Strategies to enhance the potency of NK cell-mediated ADCC may improve HIV therapies and vaccines." @default.
• W1966388845 created "2016-06-24" @default.
• W1966388845 creator A5010924026 @default.
• W1966388845 creator A5011139836 @default.
• W1966388845 creator A5028866876 @default.
• W1966388845 creator A5045201774 @default.
• W1966388845 creator A5054025307 @default.
• W1966388845 creator A5063510097 @default.
• W1966388845 creator A5070958985 @default.
• W1966388845 date "2012-04-15" @default.
• W1966388845 modified "2023-09-27" @default.
• W1966388845 title "HIV Infection Abrogates the Functional Advantage of Natural Killer Cells Educated through KIR3DL1/HLA-Bw4 Interactions To Mediate Anti-HIV Antibody-Dependent Cellular Cytotoxicity" @default.
• W1966388845 cites W1626602153 @default.
• W1966388845 cites W1893107355 @default.
• W1966388845 cites W1964095244 @default.
• W1966388845 cites W1964778946 @default.
• W1966388845 cites W1970264918 @default.
• W1966388845 cites W1974219867 @default.
• W1966388845 cites W1983310339 @default.
• W1966388845 cites W1989554591 @default.
• W1966388845 cites W1998353180 @default.
• W1966388845 cites W1999782096 @default.
• W1966388845 cites W2019812632 @default.
• W1966388845 cites W2025160449 @default.
• W1966388845 cites W2030129290 @default.
• W1966388845 cites W2034207391 @default.
• W1966388845 cites W2037264570 @default.
• W1966388845 cites W2039638023 @default.
• W1966388845 cites W2048245039 @default.
• W1966388845 cites W2052149946 @default.
• W1966388845 cites W2054522378 @default.
• W1966388845 cites W2066532177 @default.
• W1966388845 cites W2080260596 @default.
• W1966388845 cites W2087580642 @default.
• W1966388845 cites W2095603321 @default.
• W1966388845 cites W2099242520 @default.
• W1966388845 cites W2111150414 @default.
• W1966388845 cites W2115275175 @default.
• W1966388845 cites W2128306333 @default.
• W1966388845 cites W2131389039 @default.
• W1966388845 cites W2159676781 @default.
• W1966388845 cites W2163041000 @default.
• W1966388845 cites W2163802631 @default.
• W1966388845 cites W2165232639 @default.
• W1966388845 cites W2171040742 @default.
• W1966388845 cites W2316878284 @default.
• W1966388845 doi "https://doi.org/10.1128/jvi.06112-11" @default.
• W1966388845 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3318670" @default.
• W1966388845 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22345455" @default.
• W1966388845 hasPublicationYear "2012" @default.
• W1966388845 type Work @default.
• W1966388845 sameAs 1966388845 @default.
• W1966388845 citedByCount "48" @default.
• W1966388845 countsByYear W19663888452012 @default.
• W1966388845 countsByYear W19663888452013 @default.
• W1966388845 countsByYear W19663888452014 @default.
• W1966388845 countsByYear W19663888452015 @default.
• W1966388845 countsByYear W19663888452016 @default.
• W1966388845 countsByYear W19663888452017 @default.
• W1966388845 countsByYear W19663888452018 @default.
• W1966388845 countsByYear W19663888452019 @default.
• W1966388845 countsByYear W19663888452020 @default.
• W1966388845 countsByYear W19663888452021 @default.
• W1966388845 countsByYear W19663888452022 @default.
• W1966388845 crossrefType "journal-article" @default.
• W1966388845 hasAuthorship W1966388845A5010924026 @default.
• W1966388845 hasAuthorship W1966388845A5011139836 @default.
• W1966388845 hasAuthorship W1966388845A5028866876 @default.
• W1966388845 hasAuthorship W1966388845A5045201774 @default.
• W1966388845 hasAuthorship W1966388845A5054025307 @default.
• W1966388845 hasAuthorship W1966388845A5063510097 @default.
• W1966388845 hasAuthorship W1966388845A5070958985 @default.
• W1966388845 hasBestOaLocation W19663888451 @default.
• W1966388845 hasConcept C147483822 @default.
• W1966388845 hasConcept C154317977 @default.
• W1966388845 hasConcept C159654299 @default.
• W1966388845 hasConcept C170493617 @default.
• W1966388845 hasConcept C179464577 @default.
• W1966388845 hasConcept C188280979 @default.
• W1966388845 hasConcept C202751555 @default.
• W1966388845 hasConcept C203014093 @default.
• W1966388845 hasConcept C2776090121 @default.
• W1966388845 hasConcept C40677261 @default.
• W1966388845 hasConcept C49802076 @default.
• W1966388845 hasConcept C542903549 @default.
• W1966388845 hasConcept C553184892 @default.
• W1966388845 hasConcept C55493867 @default.
• W1966388845 hasConcept C86803240 @default.
• W1966388845 hasConcept C8891405 @default.
• W1966388845 hasConceptScore W1966388845C147483822 @default.
• W1966388845 hasConceptScore W1966388845C154317977 @default.
• W1966388845 hasConceptScore W1966388845C159654299 @default.
• W1966388845 hasConceptScore W1966388845C170493617 @default.
• W1966388845 hasConceptScore W1966388845C179464577 @default.
• W1966388845 hasConceptScore W1966388845C188280979 @default.
• W1966388845 hasConceptScore W1966388845C202751555 @default.
• W1966388845 hasConceptScore W1966388845C203014093 @default.
• W1966388845 hasConceptScore W1966388845C2776090121 @default.

• next