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• W1966390821 abstract "ABSTRACT Herpes simplex viruses lacking the virion host shutoff function (Δvhs) are avirulent and hypersensitive to type I and type II interferon (IFN). In this study, we demonstrate that even in the absence of IFN responses in AG129 (IFN-αβγR −/− ) mice, Δvhs remains highly attenuated via corneal infection but is fully virulent via intracranial infection. The data demonstrate that the interferon-independent inherent replication defect of Δvhs has a significant impact upon peripheral replication and neuroinvasion." @default.
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• W1966390821 date "2012-07-15" @default.
• W1966390821 modified "2023-09-25" @default.
• W1966390821 title "Corneal Replication Is an Interferon Response-Independent Bottleneck for Virulence of Herpes Simplex Virus 1 in the Absence of Virion Host Shutoff" @default.
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• W1966390821 doi "https://doi.org/10.1128/jvi.00761-12" @default.
• W1966390821 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3416281" @default.
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