Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966391978> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1966391978 endingPage "827" @default.
- W1966391978 startingPage "819" @default.
- W1966391978 abstract "Protein kinase C inhibitor was injected intracellularly by iontophoresis into CA1 somata either before or after long-term potentiation in the hippocampal slice preparation. Two different protein kinase C inhibitors, polymyxin B (PMXB) or 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), injected 10 min before long-term potentiation induction caused potentiated responses to return to baseline 15-35 min after induction without significantly affecting the initial magnitude of potentiation. There was no effect on long-term potentiation persistence when H-7 or PMXB was injected intracellularly 5 min after long-term potentiation induction. In contrast, focal extracellular micro-pressure ejection of protein kinase C inhibitor in the stratum radiatum, 15 or 30 min, but not 60 min after long-term potentiation induction caused decay of long-term potentiation to baseline. This is probably a presynaptic action since intracellular inhibitors injected postsynaptically were ineffective 5 min after long-term potentiation induction. Focal application to stratum pyramidale produced a weaker decay than to stratum radiatum suggesting a Schaffer collateral presynaptic terminal site of action. We propose that activation of postsynaptic protein kinase C activity is necessary for long-term potentiation persistence but this activity persists for less than 5 min after induction. Presynaptic protein kinase C activity is also necessary for persistence and is time-limited to less than 60 min. It is attractive to think that these two events are sequentially activated and employ different protein kinase C subtypes differentially localized to presynaptic or postsynaptic elements." @default.
- W1966391978 created "2016-06-24" @default.
- W1966391978 creator A5001683542 @default.
- W1966391978 creator A5014319407 @default.
- W1966391978 creator A5033654426 @default.
- W1966391978 date "1992-08-01" @default.
- W1966391978 modified "2023-09-23" @default.
- W1966391978 title "Postsynaptic then presynaptic protein kinase C activity may be necessary for long-term potentiation" @default.
- W1966391978 cites W1958684497 @default.
- W1966391978 cites W1964671285 @default.
- W1966391978 cites W1973454785 @default.
- W1966391978 cites W1985695864 @default.
- W1966391978 cites W1989719327 @default.
- W1966391978 cites W1994611219 @default.
- W1966391978 cites W1996892917 @default.
- W1966391978 cites W1999488417 @default.
- W1966391978 cites W2010254256 @default.
- W1966391978 cites W2010831794 @default.
- W1966391978 cites W2010920096 @default.
- W1966391978 cites W2012974904 @default.
- W1966391978 cites W2013100512 @default.
- W1966391978 cites W2027513282 @default.
- W1966391978 cites W2031347547 @default.
- W1966391978 cites W2037512229 @default.
- W1966391978 cites W2039369655 @default.
- W1966391978 cites W2044851240 @default.
- W1966391978 cites W2053980163 @default.
- W1966391978 cites W2059262499 @default.
- W1966391978 cites W2072731296 @default.
- W1966391978 cites W2080423414 @default.
- W1966391978 cites W2081966223 @default.
- W1966391978 cites W2082691527 @default.
- W1966391978 cites W2083953820 @default.
- W1966391978 cites W2094474445 @default.
- W1966391978 cites W2095538139 @default.
- W1966391978 cites W2121544019 @default.
- W1966391978 cites W2135526008 @default.
- W1966391978 cites W2157365188 @default.
- W1966391978 cites W2160347148 @default.
- W1966391978 cites W4214868137 @default.
- W1966391978 doi "https://doi.org/10.1016/0306-4522(92)90359-a" @default.
- W1966391978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1436483" @default.
- W1966391978 hasPublicationYear "1992" @default.
- W1966391978 type Work @default.
- W1966391978 sameAs 1966391978 @default.
- W1966391978 citedByCount "63" @default.
- W1966391978 countsByYear W19663919782015 @default.
- W1966391978 crossrefType "journal-article" @default.
- W1966391978 hasAuthorship W1966391978A5001683542 @default.
- W1966391978 hasAuthorship W1966391978A5014319407 @default.
- W1966391978 hasAuthorship W1966391978A5033654426 @default.
- W1966391978 hasConcept C169760540 @default.
- W1966391978 hasConcept C170493617 @default.
- W1966391978 hasConcept C184235292 @default.
- W1966391978 hasConcept C195794163 @default.
- W1966391978 hasConcept C197341189 @default.
- W1966391978 hasConcept C25274449 @default.
- W1966391978 hasConcept C2778039732 @default.
- W1966391978 hasConcept C55493867 @default.
- W1966391978 hasConcept C86803240 @default.
- W1966391978 hasConcept C95444343 @default.
- W1966391978 hasConcept C97029542 @default.
- W1966391978 hasConceptScore W1966391978C169760540 @default.
- W1966391978 hasConceptScore W1966391978C170493617 @default.
- W1966391978 hasConceptScore W1966391978C184235292 @default.
- W1966391978 hasConceptScore W1966391978C195794163 @default.
- W1966391978 hasConceptScore W1966391978C197341189 @default.
- W1966391978 hasConceptScore W1966391978C25274449 @default.
- W1966391978 hasConceptScore W1966391978C2778039732 @default.
- W1966391978 hasConceptScore W1966391978C55493867 @default.
- W1966391978 hasConceptScore W1966391978C86803240 @default.
- W1966391978 hasConceptScore W1966391978C95444343 @default.
- W1966391978 hasConceptScore W1966391978C97029542 @default.
- W1966391978 hasIssue "4" @default.
- W1966391978 hasLocation W19663919781 @default.
- W1966391978 hasLocation W19663919782 @default.
- W1966391978 hasOpenAccess W1966391978 @default.
- W1966391978 hasPrimaryLocation W19663919781 @default.
- W1966391978 hasRelatedWork W1991089100 @default.
- W1966391978 hasRelatedWork W2016191963 @default.
- W1966391978 hasRelatedWork W2018560968 @default.
- W1966391978 hasRelatedWork W2029611263 @default.
- W1966391978 hasRelatedWork W2048465471 @default.
- W1966391978 hasRelatedWork W2068246902 @default.
- W1966391978 hasRelatedWork W2085331090 @default.
- W1966391978 hasRelatedWork W2086043621 @default.
- W1966391978 hasRelatedWork W2287061889 @default.
- W1966391978 hasRelatedWork W2571559752 @default.
- W1966391978 hasVolume "49" @default.
- W1966391978 isParatext "false" @default.
- W1966391978 isRetracted "false" @default.
- W1966391978 magId "1966391978" @default.
- W1966391978 workType "article" @default.