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- W1966394402 abstract "Abstract The effects of the pyrethroids allethrin, 1 R-cis -cyphenothrin, 1 R-cis -fenfluthrin, and of the noninsecticidal isomer 1 S-cis -fenfluthrin on neurotransmitter receptor-mediated membrane responses have been investigated in the mouse neuroblastoma cell line N1E-115 using electrophysiological methods. At a concentration of 10 μ M , allethrin and 1 R-cis -cyphenothrin caused a reduction of the peak amplitude of the nicotinic membrane depolarization to half of the control value. In voltage-clamped cells the peak amplitude of the nicotinic ACh receptor-mediated inward current was reduced to 50–75% of the control value by the pyrethroids at a concentration of 1 μ M . The effects of the insecticidal and the noninsecticidal isomer of fenfluthrin were identical. The amplitudes of the ACh and the serotonin 5-HT 3 receptor-mediated inward currents were equally reduced by 10 μ M 1 R-cis -cyphenothrin. The effects were partially reversed by washing. Steady-state desensitization, induced with a low concentration of ACh, was increased by 1 μ M allethrin and by 1 μ M 1 S-cis -fenfluthrin to a similar extent. The rate of desensitization was not affected. Ion channel block, additionally observed at high concentrations of ACh, was facilitated by all pyrethroids investigated. It is concluded that the pyrethroids exert nonspecific, inhibitory effects on neurotransmitter receptor-operated ion channels. These effects are unlikely to contribute to the excitatory symptoms of these insecticides." @default.
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- W1966394402 date "1989-06-01" @default.
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- W1966394402 title "Effects of pyrethroids on neurotransmitter-operated ion channels in cultured mouse neuroblastoma cells" @default.
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- W1966394402 doi "https://doi.org/10.1016/0048-3575(89)90154-5" @default.
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