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- W1966398434 abstract "Calcium oscillations exert physiological control on mitochondrial energy metabolism and can also lead to mitochondrial membrane permeabilization and cell death. The outcome of the mitochondrial calcium signaling is altered by stress factors such as ceramide or staurosporine. However, the mechanism of this proapoptotic switch remains unclear. Using genetic, biochemical, pharmacological, and functional approaches, we here show that ceramide and staurosporine target PP2A and protein kinases A and C, respectively, in a mitochondria-associated signaling complex to induce dephosphorylation of the BH3-only protein Bad. Dephosphorylated Bad sensitizes the mitochondrial permeability transition pore (PTP) to Ca2+ through a Bcl-xL-sensitive and VDAC-mediated process. Furthermore, the Bad-induced sensitization of the PTP to Ca2+ does not require Bax or Bak. Thus, phospho-regulatory mechanisms converge on Bad to switch between the survival and apoptotic functions of mitochondrial calcium signaling by activating a mechanism whereby a BH3-only protein bypasses Bax/Bak and engages the PTP." @default.
- W1966398434 created "2016-06-24" @default.
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- W1966398434 date "2009-02-01" @default.
- W1966398434 modified "2023-10-17" @default.
- W1966398434 title "Bad Targets the Permeability Transition Pore Independent of Bax or Bak to Switch between Ca2+-Dependent Cell Survival and Death" @default.
- W1966398434 cites W1493090551 @default.
- W1966398434 cites W1581414531 @default.
- W1966398434 cites W1607531254 @default.
- W1966398434 cites W1679452661 @default.
- W1966398434 cites W1900078466 @default.
- W1966398434 cites W1948525638 @default.
- W1966398434 cites W1964483580 @default.
- W1966398434 cites W1968091649 @default.
- W1966398434 cites W1968789295 @default.
- W1966398434 cites W1972414420 @default.
- W1966398434 cites W1976720365 @default.
- W1966398434 cites W1978008790 @default.
- W1966398434 cites W1978301210 @default.
- W1966398434 cites W1978559408 @default.
- W1966398434 cites W1979139758 @default.
- W1966398434 cites W1980543406 @default.
- W1966398434 cites W1980837484 @default.
- W1966398434 cites W1983755623 @default.
- W1966398434 cites W1984547206 @default.
- W1966398434 cites W1986568749 @default.
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- W1966398434 cites W2000011855 @default.
- W1966398434 cites W2002208801 @default.
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- W1966398434 cites W2008841394 @default.
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- W1966398434 cites W2072225072 @default.
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- W1966398434 doi "https://doi.org/10.1016/j.molcel.2009.01.018" @default.
- W1966398434 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2662194" @default.
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