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• W1966398859 startingPage "235" @default.
• W1966398859 abstract "Hepatocyte growth factor (HGF) functions as a hepatotrophic and renotrophic factor for regeneration of the liver and kidney. When 1 ng/ml of interleukin-1α (IL-1α) or interleukin-1β (IL-1β) was added to cultures of human skin fibroblasts, the production of HGF was 5–6 fold higher than levels in the controls. HGF mRNA level in the cells was increased to 4-fold higher levels at 6 h after exposure to IL- 1α. Tumor necrosis factor-α and interferon-γ but no other cytokine tested had slightly stimulatory effects on HGF production. The tumor promoter, tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the stimulatory effect of IL-1α and IL-1β on the production of HGF. The stimulatory effect of both IL-1α and IL-1β and the synergistical stimulation with TPA were completely abrogated by 10 ng/ml TGF-β 1 or 1 μM dexamethasone. These results suggest that IL-1α and IL-1β are positive regulators for expression of the HGF gene and are likely have a role in regeneration of tissues following the occurrence of inflammatory diseases." @default.
• W1966398859 created "2016-06-24" @default.
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• W1966398859 date "1992-10-01" @default.
• W1966398859 modified "2023-10-18" @default.
• W1966398859 title "Up-regulation of hepatocyte growth factor gene expression by interleukin-1 in human skin fibroblasts" @default.
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• W1966398859 doi "https://doi.org/10.1016/0006-291x(92)92375-8" @default.
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