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• W1966403257 abstract "The endopeptidase furin and the trans-Golgi network protein TGN38 are membrane proteins that recycle between the TGN and plasma membrane. TGN38 is transported by a retromer-dependent pathway from early endosomes to the TGN, whereas the intracellular transport of furin is poorly defined. Here we have identified the itinerary and transport requirements of furin. Using internalisation assays, we show that furin transits the early and late endosomes en route to the TGN. The GTPase Rab9 and the TGN golgin GCC185, components of the late endosome-to-TGN pathway, were required for efficient TGN retrieval of furin. By contrast, TGN38 trafficking was independent of Rab9 and GCC185. To identify the sorting signals for the early endosome-to-TGN pathway, the trafficking of furin–TGN38 chimeras was investigated. The diversion of furin from the Rab9-dependent late-endosome-to-TGN pathway to the retromer-dependent early-endosome-to-TGN pathway required both the transmembrane domain and cytoplasmic tail of TGN38. We present evidence to suggest that the length of the transmembrane domain is a contributing factor in endosomal sorting. Overall, these data show that furin uses the Rab9-dependent pathway from late endosomes and that retrograde transport directly from early endosomes is dependent on both the transmembrane domain and the cytoplasmic tail." @default.
• W1966403257 created "2016-06-24" @default.
• W1966403257 creator A5010308411 @default.
• W1966403257 creator A5048338669 @default.
• W1966403257 creator A5052519554 @default.
• W1966403257 creator A5061086682 @default.
• W1966403257 date "2011-07-15" @default.
• W1966403257 modified "2023-10-14" @default.
• W1966403257 title "Rab9-dependent retrograde transport and endosomal sorting of the endopeptidase furin" @default.
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• W1966403257 doi "https://doi.org/10.1242/jcs.083782" @default.
• W1966403257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3124371" @default.
• W1966403257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21693586" @default.
• W1966403257 hasPublicationYear "2011" @default.
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