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• W1966403930 abstract "Abstract A series of tricyclohexyl‐ and triphenylphosphine boranes, carboxyboranes and cyanoboranes were synthesized. These compounds have potent hypolipidemic effects, antineoplastic and antiinflammatory activities in rodents. Furthermore, they demonstrated potent cyctotoxicity against standard human tissue culture lines. The compounds which afforded the best hypolipidemic activity, i.e. greater than 40% reduction of serum cholesterol and triglyceride levels, were diphenyl‐(4‐methylphenyl)‐phosphine borane and triphenylphosphine carboxyborane. Other derivatives demonstrated more potent antineoplastic activity against the Ehrlich ascites carcinoma growth including triphenylphosphine cyanoborane, 2‐amino‐4‐methyl‐pyridine cyanoborane and 2‐amino‐pyridine cyanoborane. Most of the derivatives showed good activity against murine L 1210 lymphoid leukemia, Tmolt 3 human leukemia, uterine HeLa S cells, and human glioma cell growth. Select compounds were active against colon adenocarcinoma, KB nasopharynx, lung bronchogenic and osteosarcoma cell growth. Tricyclohexyl‐ and triphenylphosphine boranes and the carboxy derivatives of the latter borane demonstrated good antiinflammatory activity." @default.
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• W1966403930 date "1992-01-01" @default.
• W1966403930 modified "2023-10-07" @default.
• W1966403930 title "Relationship of Hypolipidemic and Antineoplastic Activities of Tricyclohexyl- and Triphenylphosphine Boranes, Carboxyboranes, Cyanoboranes, and Related Derivatives" @default.
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• W1966403930 doi "https://doi.org/10.1002/ardp.19923250504" @default.
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