Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966408243> ?p ?o ?g. }
- W1966408243 endingPage "2244" @default.
- W1966408243 startingPage "2233" @default.
- W1966408243 abstract "Among food allergies, peanut allergy is frequently associated with severe anaphylactic reactions. In the need for safe and effective therapeutic strategies, probiotics may be considered on the basis of their immunomodulatory properties. The aim of the present study was to investigate the immunological mediators involved in the effects of probiotic VSL#3 oral supplementation on Th2 inflammation and anaphylaxis in a mouse model of peanut allergy.VSL#3 supplementation to peanut-sensitized mice was effective in ameliorating anaphylaxis and Th2-mediated inflammation, by promoting regulatory responses in the jejunum mucosa and in the mesenteric lymph node, as evaluated by ELISA, real-time PCR, histologic, and immunohistochemical analysis. Probiotic-induced TGF-β mediates its protective effects through the induction of regulatory T cells expressing FOXP3 and/or latency-associated peptide, as proven by in vivo blockade of TGF-β in VSL#3-treated mice with a neutralizing monoclonal antibody one day before challenge.TGF-β, induced in the gut by VSL#3 supplementation, is capable of reducing the Th2 inflammation associated with food anaphylaxis in a mouse model of peanut sensitization. TGF-β acts through the induction/maintenance of regulatory T cells expressing FOXP3 and/or latency-associated peptide. Probiotics supplementation may represent an effective and safe strategy for treating food allergies in adult population." @default.
- W1966408243 created "2016-06-24" @default.
- W1966408243 creator A5004018884 @default.
- W1966408243 creator A5021682735 @default.
- W1966408243 creator A5042946289 @default.
- W1966408243 creator A5043600121 @default.
- W1966408243 creator A5050832568 @default.
- W1966408243 creator A5069716314 @default.
- W1966408243 creator A5077194201 @default.
- W1966408243 date "2013-08-14" @default.
- W1966408243 modified "2023-10-05" @default.
- W1966408243 title "Probiotic VSL#3-induced TGF-β ameliorates food allergy inflammation in a mouse model of peanut sensitization through the induction of regulatory T cells in the gut mucosa" @default.
- W1966408243 cites W1485478411 @default.
- W1966408243 cites W1502746512 @default.
- W1966408243 cites W1575606714 @default.
- W1966408243 cites W1601070312 @default.
- W1966408243 cites W1806886352 @default.
- W1966408243 cites W1972505691 @default.
- W1966408243 cites W1981859401 @default.
- W1966408243 cites W1982061234 @default.
- W1966408243 cites W1988336320 @default.
- W1966408243 cites W1989102837 @default.
- W1966408243 cites W1991579347 @default.
- W1966408243 cites W2004785338 @default.
- W1966408243 cites W2008121639 @default.
- W1966408243 cites W2010475500 @default.
- W1966408243 cites W2012138234 @default.
- W1966408243 cites W2018505426 @default.
- W1966408243 cites W2019630627 @default.
- W1966408243 cites W2035506432 @default.
- W1966408243 cites W2035968976 @default.
- W1966408243 cites W2036838490 @default.
- W1966408243 cites W2037873372 @default.
- W1966408243 cites W2047889730 @default.
- W1966408243 cites W2048706422 @default.
- W1966408243 cites W2061864335 @default.
- W1966408243 cites W2063053656 @default.
- W1966408243 cites W2085059541 @default.
- W1966408243 cites W2087916051 @default.
- W1966408243 cites W2100357356 @default.
- W1966408243 cites W2100842618 @default.
- W1966408243 cites W2103328685 @default.
- W1966408243 cites W2105074430 @default.
- W1966408243 cites W2114424280 @default.
- W1966408243 cites W2116645352 @default.
- W1966408243 cites W2121101100 @default.
- W1966408243 cites W2123013608 @default.
- W1966408243 cites W2127285081 @default.
- W1966408243 cites W2128680214 @default.
- W1966408243 cites W2132488375 @default.
- W1966408243 cites W2133233731 @default.
- W1966408243 cites W2145678343 @default.
- W1966408243 cites W2146068085 @default.
- W1966408243 cites W2149755871 @default.
- W1966408243 cites W2153509933 @default.
- W1966408243 cites W2157828485 @default.
- W1966408243 cites W2165174834 @default.
- W1966408243 cites W2165257283 @default.
- W1966408243 cites W2170617867 @default.
- W1966408243 cites W4244649778 @default.
- W1966408243 doi "https://doi.org/10.1002/mnfr.201300028" @default.
- W1966408243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23943347" @default.
- W1966408243 hasPublicationYear "2013" @default.
- W1966408243 type Work @default.
- W1966408243 sameAs 1966408243 @default.
- W1966408243 citedByCount "35" @default.
- W1966408243 countsByYear W19664082432014 @default.
- W1966408243 countsByYear W19664082432015 @default.
- W1966408243 countsByYear W19664082432016 @default.
- W1966408243 countsByYear W19664082432017 @default.
- W1966408243 countsByYear W19664082432018 @default.
- W1966408243 countsByYear W19664082432019 @default.
- W1966408243 countsByYear W19664082432020 @default.
- W1966408243 countsByYear W19664082432021 @default.
- W1966408243 countsByYear W19664082432022 @default.
- W1966408243 countsByYear W19664082432023 @default.
- W1966408243 crossrefType "journal-article" @default.
- W1966408243 hasAuthorship W1966408243A5004018884 @default.
- W1966408243 hasAuthorship W1966408243A5021682735 @default.
- W1966408243 hasAuthorship W1966408243A5042946289 @default.
- W1966408243 hasAuthorship W1966408243A5043600121 @default.
- W1966408243 hasAuthorship W1966408243A5050832568 @default.
- W1966408243 hasAuthorship W1966408243A5069716314 @default.
- W1966408243 hasAuthorship W1966408243A5077194201 @default.
- W1966408243 hasConcept C141105273 @default.
- W1966408243 hasConcept C159654299 @default.
- W1966408243 hasConcept C203014093 @default.
- W1966408243 hasConcept C207480886 @default.
- W1966408243 hasConcept C2775933838 @default.
- W1966408243 hasConcept C2776027960 @default.
- W1966408243 hasConcept C2776090121 @default.
- W1966408243 hasConcept C2776217527 @default.
- W1966408243 hasConcept C2776914184 @default.
- W1966408243 hasConcept C2778012357 @default.
- W1966408243 hasConcept C2778296632 @default.
- W1966408243 hasConcept C2779675166 @default.
- W1966408243 hasConcept C2779727006 @default.
- W1966408243 hasConcept C2780255968 @default.