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• W1966411920 endingPage "1909" @default.
• W1966411920 startingPage "1906" @default.
• W1966411920 abstract "CD25 expression occurs early in thymocyte differentiation. The mechanism of induction of CD25 before T cell receptor rearrangement and the importance of this mechanism for T cell development are unknown. In a thymus reconstitution assay, tumor necrosis factor α (TNF-α) and interleukin-1α (IL-1α), two cytokines produced within the thymic microenvironment, induced CD25 expression on early immature thymocytes. Either TNF-α or IL-1α was necessary for further thymocyte maturation and CD4+CD8+ differentiation. In irradiated mice reconstituted with CD117+CD25+ thymocytes, commitment to the T cell lineage was marked by the loss of precursor multipotency." @default.
• W1966411920 created "2016-06-24" @default.
• W1966411920 creator A5038437356 @default.
• W1966411920 creator A5044412037 @default.
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• W1966411920 date "1995-06-30" @default.
• W1966411920 modified "2023-09-23" @default.
• W1966411920 title "Requirement for TNF-α and IL-1α in Fetal Thymocyte Commitment and Differentiation" @default.
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• W1966411920 doi "https://doi.org/10.1126/science.7541554" @default.
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