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- W1966413612 abstract "Duncan Odom and colleagues map Pol III occupancy genome-wide in liver tissue from six mammals. The analysis showed variable binding of Pol III at individual tRNA genes that nevertheless led to conserved expression of amino acid isotypes. RNA polymerase III (Pol III) transcription of tRNA genes is essential for generating the tRNA adaptor molecules that link genetic sequence and protein translation. By mapping Pol III occupancy genome-wide in mouse, rat, human, macaque, dog and opossum livers, we found that Pol III binding to individual tRNA genes varies substantially in strength and location. However, when we took into account tRNA redundancies by grouping Pol III occupancy into 46 anticodon isoacceptor families or 21 amino acid–based isotype classes, we discovered strong conservation. Similarly, Pol III occupancy of amino acid isotypes is almost invariant among transcriptionally and evolutionarily diverse tissues in mouse. Thus, synthesis of functional tRNA isotypes has been highly constrained, although the usage of individual tRNA genes has evolved rapidly." @default.
- W1966413612 created "2016-06-24" @default.
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- W1966413612 date "2011-08-28" @default.
- W1966413612 modified "2023-10-11" @default.
- W1966413612 title "Pol III binding in six mammals shows conservation among amino acid isotypes despite divergence among tRNA genes" @default.
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- W1966413612 doi "https://doi.org/10.1038/ng.906" @default.
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